Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

Endocrinology
Sarah J LessardMatthew J Watt

Abstract

We hypothesized that improved glucose tolerance with rosiglitazone treatment would coincide with decreased levels of i.m. triacylglycerol (IMTG), diacylglycerol, and ceramide. Obese Zucker rats were randomly divided into two experimental groups: control (n = 9) and rosiglitazone (n = 9), with lean Zucker rats (n = 9) acting as a control group for obese controls. Rats received either vehicle or 3 mg/kg rosiglitazone for 6 wk. Glucose tolerance was impaired (P < 0.01) in obese compared with lean rats, but was normalized after rosiglitazone treatment. IMTG content was higher in obese compared with lean rats (70.5 +/- 5.1 vs. 27.5 +/- 2.0 micromol/g dry mass; P < 0.05) and increased an additional 30% (P < 0.05) with rosiglitazone treatment. Intramuscular fatty acid composition shifted toward a higher proportion of monounsaturates (P < 0.05) in obese rosiglitazone-treated rats due to an increase in palmitoleate (16:1; P < 0.05). Rosiglitazone treatment increased (P < 0.05) skeletal muscle diacylglycerol and ceramide levels by 65% and 100%, respectively, compared with obese rats, but elevated muscle diacylglycerol was not associated with changes in the total or membrane contents of the diacylglycerol-sensitive protein kinase C isofor...Continue Reading

References

Feb 26, 2000·Metabolism: Clinical and Experimental·M MancoG Gasbarrini
Jul 21, 2000·The Journal of Clinical Investigation·G I Shulman
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J K KimG I Shulman
Nov 22, 2001·The Journal of Biological Chemistry·Guenter HaemmerleRudolf Zechner
Jun 11, 2002·Annual Review of Nutrition·David E KelleyLen Storlien
Jan 15, 2003·The Journal of Biological Chemistry·Jose Antonio ChavezScott A Summers
Apr 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Hubertina M WilmsenRobert R Henry
Aug 5, 2003·Metabolism: Clinical and Experimental·Martin MuurlingPeter J Voshol
Dec 4, 2003·Biochemical Society Transactions·C Holm
Dec 25, 2003·Diabetes·John M AdamsLawrence J Mandarino
Mar 26, 2004·Reviews in Endocrine & Metabolic Disorders·Martin Krssak, Michael Roden

❮ Previous
Next ❯

Citations

Jun 17, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J G KempG M M Stephenson
Jul 10, 2013·Lipids in Health and Disease·Sehamuddin GaladariFaisal Thayyullathil
Jun 13, 2008·The Review of Diabetic Studies : RDS·Marek Straczkowski, Irina Kowalska
Feb 26, 2010·Journal of Oncology·L D KellenbergerJ Petrik
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David C Wright
Jan 8, 2016·Hormone Molecular Biology and Clinical Investigation·Claire Laurens, Cedric Moro
Jun 15, 2006·Mayo Clinic Proceedings·Craig S StumpJames R Sowers
Jan 30, 2007·Prostaglandins & Other Lipid Mediators·Marcin BaranowskiJan Gorski
May 12, 2015·Diabetes/metabolism Research and Reviews·Jeremy T WarshauerIldiko Lingvay
Oct 20, 2009·Biochimica Et Biophysica Acta·Juan Carlos MoleroKen Walder
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas D OakesBengt Ljung
Dec 24, 2005·Physiological Reviews·Bente Kiens
Apr 29, 2006·The Journal of Physiology·Matthew J WattMark A Febbraio
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Mireille J SerlieHans P Sauerwein
Feb 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Fiona J SpargoJohn A Hawley
Jul 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Robert C NolandRonald N Cortright
Jul 9, 2009·Physiological Reviews·Gregory R Steinberg, Bruce E Kemp
Feb 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A Brianne ThrushDavid J Dyck
Oct 5, 2019·Animal : an International Journal of Animal Bioscience·X LiM Du
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Mark K ToddLorraine P Turcotte
Jul 12, 2007·American Journal of Physiology. Endocrinology and Metabolism·Ben B YaspelkisJohn A Hawley
Jan 15, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donato A RivasRoger A Fielding
Aug 25, 2005·American Journal of Physiology. Endocrinology and Metabolism·Sarah J LessardJohn A Hawley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.