Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

Molecular Medicine Reports
Junchao YaoXiang Zhang

Abstract

Traumatic brain injury (TBI) is one of the leading causes of mortality and morbidity in adults and children worldwide. Recent studies have demonstrated that both apoptosis and autophagy participate in TBI‑induced neuronal cell death and functional loss. The peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) agonist rosiglitazone (RSG) is a well‑known anti‑inflammatory, which carries out its effects via the activation of PPAR‑γ. Previous studies have suggested that RSG may exert neuroprotective effects in animal models of both chronic and acute brain injury; however, whether RSG is involved in autophagic neuronal death following TBI remains to be elucidated. The present study aimed to determine whether RSG carries out its neuroprotective properties via the attenuation of neuronal apoptosis and autophagy, following TBI in a rat model. Furthermore, the role of RSG was investigated with regards to the modulation of inflammation and glutamate excitotoxicity, and the impact of RSG on functional recovery following TBI was determined. The rats were subjected to controlled cortical impact injury, prior to being randomly divided into three groups: A sham‑operated group, a TBI group, and an RSG treatment group. The RSG treatment group ...Continue Reading

References

Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P HeadrickR Vink
Jan 26, 2000·Journal of Neurochemistry·R S ClarkS H Graham
Nov 4, 2000·Journal of Neurotrauma·S H GrahamR S Clark
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michael Gaetz
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Priya MohantyParesh Dandona
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Burkhard SchützMichael T Heneka
Feb 1, 2006·The Pharmacogenomics Journal·M E RisnerUNKNOWN Rosiglitazone in Alzheimer's Disease Study Group
Feb 14, 2006·Neurochemistry International·Jae-Hyuk Yi, Alan S Hazell
Feb 3, 2007·Neurobiology of Disease·S ErlichR Pinkas-Kramarski
Sep 6, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yichen LaiRobert S B Clark
Sep 26, 2007·Cell Research·Yang Cao, Daniel J Klionsky
Apr 4, 2008·Journal of Neurochemistry·Rajnish K Chaturvedi, M Flint Beal
Mar 24, 2009·The Mount Sinai Journal of Medicine, New York·Mark W Greve, Brian J Zink
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bogdan A Stoica, Alan I Faden
Jun 28, 2012·Neurochemical Research·Yao-Qi WangLu-Yang Tao
Nov 28, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Changmeng CuiJianzhong Cui

❮ Previous
Next ❯

Citations

Feb 15, 2018·Journal of Neuroinflammation·Charu GargJorge E Contreras
Jun 4, 2016·Nature Reviews. Neuroscience·Lorenzo GalluzziGuido Kroemer
Sep 13, 2019·Journal of Cellular Physiology·Zhiqing ZengHongtao Qu
Aug 8, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hongjian PuJun Chen
Jun 21, 2018·Frontiers in Molecular Neuroscience·Li Zhang, Handong Wang
Dec 11, 2019·International Journal of Molecular Sciences·Jain HaSayeon Cho
Dec 7, 2020·Behavioural Brain Research·Laura Martínez-DrudisMargalida Coll-Andreu
Feb 3, 2021·Fundamental & Clinical Pharmacology·Dominique LerouetValérie C Besson
Oct 13, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa
Oct 1, 2021·Frontiers in Cellular Neuroscience·Jason H Y YeungAndrea Kwakowsky

❮ Previous
Next ❯

Software Mentioned

- ASW
SPSS
ImageJ
FV10

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis