Rosiglitazone improves contextual fear conditioning in aged rats

Neuroreport
Carmelina GemmaPaula C Bickford

Abstract

Experimental, clinical, and epidemiologic studies indicate that non-steroidal anti-inflammatory drugs (NSAIDs) are beneficial in Alzheimer's disease and other neuroinflammatory processes. One possible mechanism is an interaction with peroxisome proliferator-activated receptors (PPARs). We examined the effect of a specific PPARgamma agonist, rosiglitazone, on contextual fear conditioning in aged rats. Male rats (20-months-old) were administered rosiglitazone in the diet for 2 months prior to behavioral testing. Young control and aged rats fed rosiglitazone froze significantly more than did the aged control rats in a hippocampal-dependent fear conditioning task. Rosiglitazone had no effect hippocampal interleukin-1beta levels, markers of oxidative damage, and NMDA receptor expression. Therefore, activation of PPARgamma prevented age-related deficits in hippocampal function.

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Citations

Sep 22, 2012·The Journal of Clinical Investigation·Joshua D HawkTed Abel
May 6, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hong SunGang Zhao
Nov 7, 2013·Nutritional Neuroscience·Linnea R FreemanAnn-Charlotte Granholm
Jul 23, 2013·European Journal of Pharmacology·Olivier ThibaultNada M Porter
Oct 5, 2017·Cellular and Molecular Neurobiology·Sonia Villapol
Feb 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica C GasparDavid P Finn
Oct 26, 2018·Frontiers in Pharmacology·Khalin E Nisbett, Graziano Pinna

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