Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus.

Neuroscience
Ying PengYulan Zhu

Abstract

Status epilepticus (SE) leads to irreversible neuronal damage and consists of a complex pathogenesis that involves oxidative stress and subsequent autophagy. Rosiglitazone has recently been considered as a potential neuroprotective factor in epilepsy because of its antioxidative function. The aim of this study was to assess the effects of rosiglitazone in SE rat models and investigate whether its mechanisms of action involve autophagy via the antioxidant factor, nuclear factor erythroid 2-related factor 2 (Nrf2). The male Sprague-Dawley rats (200-220 g) were used to establish lithium-pilocarpine-induced SE model. We found that rosiglitazone markedly improved neuronal survival at 24-h post-SE as indicated via Hematoxylin-Eosin and Nissl staining. Furthermore, along with a reduction in reactive oxygen species, rosiglitazone pretreatment enhanced the antioxidative activity of superoxide dismutase and the expression level of Nrf2, as detected via chemical assay kits and Western blotting, respectively. In addition, the microtubule-associated protein light chain 3II (LC3II)/LC3I ratio was increased and peaked at 24 h after SE, whereas p62 mRNA levels were sharply elevated at 72 h after SE, both SE-induced increases of which were reve...Continue Reading

References

Dec 14, 2004·American Journal of Physiology. Cell Physiology·Jinah HwangC Michael Hart
Apr 22, 2008·Methods in Molecular Biology·Isei TanidaEiki Kominami
Oct 3, 2008·Antioxidants & Redox Signaling·Meghan B AzadSpencer B Gibson
May 13, 2011·Epilepsia·Tiziana GranataGiuliano Avanzini
Jun 11, 2011·Circulation Research·Qingwen ZhengXuejun Wang
Jun 16, 2011·Neurochemistry International·Eun-Joo ShinHyoung-Chun Kim
Jul 7, 2011·Current Medicinal Chemistry·L A FaineD S P Abdalla
Sep 15, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sun HongDu Yun
Feb 14, 2012·Journal of Cell Science·Stjepana KovacAndrey Y Abramov
Sep 14, 2012·Epilepsia·Rima Nabbout
May 21, 2013·Annals of Neurology·Manuela MazzuferiRafal M Kaminski
Jun 4, 2013·Antioxidants & Redox Signaling·Katherine R Parzych, Daniel J Klionsky
Jul 12, 2014·BioMed Research International·Mónika Lippai, Péter Lőw
Feb 5, 2015·BioMed Research International·Sreekanth PuttacharyThimmasettappa Thippeswamy
Jun 11, 2016·Scientific Reports·Anna WardenR Adron Harris
Oct 25, 2016·Physiological Research·M KvandováI Dovinová
May 4, 2017·Neurochemical Research·Jennifer N Pearson-SmithManisha Patel
Dec 25, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Desirée BartoliniFrancesco Galli
Mar 15, 2018·Brain : a Journal of Neurology·Tawfeeq Shekh-AhmadMatthew C Walker
Sep 15, 2018·International Journal of Molecular Sciences·Jie-Hua Xu, Feng-Ru Tang
May 17, 2019·Brain Sciences·Abdelaziz M HusseinOsama A Abulseoud
May 31, 2019·Brain : a Journal of Neurology·Alberto PaulettiAnnamaria Vezzani
Jul 14, 2019·Scientific Reports·Gautam RunwalDavid C Rubinsztein
Aug 6, 2019·Redox Biology·Tawfeeq Shekh-AhmadMatthew C Walker

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