Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression.

Biochemical and Biophysical Research Communications
Hyo-Sup KimMoon-Kyu Lee

Abstract

Peroxisome proliferator-activated receptor (PPAR)-gamma is a member of the nuclear receptor superfamily, and its ligands, the thiazolidinediones, might directly stimulate insulin release and insulin synthesis in pancreatic beta-cells. In the present study, we examined the effects of rosiglitazone (RGZ) on insulin release and synthesis in pancreatic beta-cell (INS-1). Insulin release and synthesis were stimulated by treatment with RGZ for 24h. RGZ upregulated the expressions of GLUT-2 and glucokinase (GCK). Moreover, it was found that RGZ increased the expression of BETA2/NeuroD gene which could regulate insulin gene expression. These results suggest that RGZ could stimulate the release and synthesis of insulin through the upregulation of GLUT-2, GCK, and BETA2/NeuroD gene expression.

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Citations

Mar 11, 2010·Cancer Chemotherapy and Pharmacology·Eva GottfriedMarina Kreutz
Mar 27, 2012·The Journal of Nutritional Biochemistry·Anna Castell-AuvíAnna Ardévol
Mar 30, 2010·European Journal of Pharmacology·Mandeep Kumar AroraPitchai Balakumar
Oct 20, 2009·Biochemical and Biophysical Research Communications·Ji-Won KimKun-Ho Yoon
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Apr 19, 2012·Phytotherapy Research : PTR·Woo Jin JeonGeun Eog Ji
Apr 6, 2016·Frontiers in Pharmacology·Chi Teng VongMaggie Pui Man Hoi
Jun 7, 2019·Acta Biochimica Et Biophysica Sinica·Kai ZhangYao Wang
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May 13, 2020·PPAR Research·Laurits J HolmKarsten Buschard
Jul 24, 2013·Annals of Clinical Biochemistry·Tim J McDonald, Sian Ellard
Jun 17, 2021·Journal of Cellular Physiology·Mina HwangMoon-Kyu Lee

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