Abstract
Despite several pharmacological applications of Baccaurea ramiflora Lour., studies on the influence of its polyphenol content on pharmacological activity such as anti-inflammatory properties have been scarce. Here we evaluated in vitro antioxidant activity, poyphenolics by HPLC and the anti-inflammatory potential of the methanolic leaf extract of Baccaurea ramiflora (BME) and its protective effects in carrageenan-induced paw edema model of inflammation in rats. The BME extract contained 79.06 ± 0.03 mg gallic acid equivalent (GAE)/g total polyphenols, 28.80 ± 0.01 mg quercetin equivalent (QE)/g flavonoid and 29.42 ± 0.01 μg cathechin equivalent/g proanthocyanidin respectively and rosmarinic acid (8 mg/kg) as a main component was identified by HPLC. Results demonstrate that administration of BME at the dose of 200 mg/kg can reduce paw edema by over 63%, and it exhibits a dose-response effect. Depending on concentration, the extract exerted scavenging activity on DPPH radical (IC50 36.4 μg/mL), significantly inhibited IL-1β (4.4 pg/mg protein) and TNF-α (0.21 ng/μg protein). Therefore, we conclude BME causes a substantial reduction of inflammation in in vivo models. We propose that rosmarinic acid and similar phenolic compounds m...Continue Reading
References
Jan 1, 1994·Methods in Enzymology·L MarcocciM Gardès-Albert
Apr 1, 1993·Clinical Science·N J MillerA Milner
May 1, 1999·Analytical Biochemistry·P PrietoM Aguilar
Dec 17, 2002·Phytochemistry·Maike Petersen, Monique S J Simmonds
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Jan 26, 2005·European Journal of Immunology·Mònica ComaladaAntonio Zarzuelo
Jun 21, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Chihiro TohdaKatsuko Komatsu
Sep 5, 2006·The Journal of Pain : Official Journal of the American Pain Society·L C LoramD Mitchell
Oct 6, 2007·Planta medica·Xian-Wen YangXiao-Jiang Hao
Dec 11, 2008·BMC Complementary and Alternative Medicine·Bibhabasu HazraNripendranath Mandal
Jul 11, 2009·Planta medica·Xian-Wen YangXiao-Jiang Hao
Jan 14, 2012·BMC Complementary and Alternative Medicine·Agnete E KristoffersenVinjar M Fønnebø
Jul 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·R MoganaC Wiart
Aug 29, 2013·Advances in Pharmacological Sciences·Sushil Kumar MiddhaVeena Pande
Nov 30, 2013·Journal of Biosciences·Arvind K GoyalArnab Sen
Sep 1, 2011·Functional Plant Biology : FPB·Arvind K GoyalSushil K Middha
Citations
Jan 31, 2018·BMC Complementary and Alternative Medicine·Mst Luthfun NesaMohammad Sirajum Munir
Jun 2, 2017·3 Biotech·Arvind Kumar GoyalArnab Sen
Mar 19, 2020·Frontiers in Pharmacology·Chunxu LuoShuangyong Sun
Jul 30, 2020·European Journal of Medicinal Chemistry·Kashif HaiderM Shahar Yar