Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh

Abstract

We aimed to investigate the potential prophylactic and curative effects of rosmarinic acid, one of the main constituents of rosemary, on the neuropathic pain induced by chronic constriction injury (CCI) in rats. CCI was used to induce peripheral neuropathic pain. In prophylactic groups, rosmarinic acid (10, 20, and 40 mg/kg, i.p.) was administered from the day of surgery (day 0) for 14 days. In treatment group, rosmarinic acid (40 mg/kg) was given from day 5 (after the pain was established), for 7 days. The degree of mechanical allodynia, cold allodynia, and heat hyperalgesia were measured on days 0, 3, 5, 7, 10 and 14 post-surgery. The open field test was carried out to assess locomotor activity of animals. Lumbar spinal cord levels of astroglia activation marker, glial fibrillary acidic protein (GFAP), microglial activation marker, ionized calcium-binding adapter molecule 1 (Iba-1), toll-like receptor 4 (TLR-4), tumor necrosis factor alpha (TNF-α), inducible isoform of nitric oxide synthase enzyme (iNOS) and apoptotic factors were quantified via western blot on days 7 and 14. CCI rats showed a significant mechanical allodynia, cold allodynia and thermal hyperalgesia, compared to sham ones on day 3, persisted up to day 14 post...Continue Reading

Citations

May 21, 2020·Iranian Biomedical Journal·Malek ZareiTaraneh Moini-Zanjani
Jul 26, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zineb El GabbasAbderrahman Chait
Mar 19, 2020·Frontiers in Pharmacology·Chunxu LuoShuangyong Sun
Jun 28, 2020·Phytotherapy Research : PTR·Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh
Jul 28, 2020·Journal of Biochemical and Molecular Toxicology·Yang YaoYong Wang
Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Feb 15, 2020·Phytotherapy Research : PTR·Javad Sharifi-RadNatália Martins
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad FakhriMasoumeh Jorjani
Jun 5, 2021·Nutrition and Cancer·Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh
Aug 12, 2021·Indian Journal of Nephrology·Leila JafaripourHassan Ahmadvand

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