Abstract
We aimed to investigate the potential prophylactic and curative effects of rosmarinic acid, one of the main constituents of rosemary, on the neuropathic pain induced by chronic constriction injury (CCI) in rats. CCI was used to induce peripheral neuropathic pain. In prophylactic groups, rosmarinic acid (10, 20, and 40 mg/kg, i.p.) was administered from the day of surgery (day 0) for 14 days. In treatment group, rosmarinic acid (40 mg/kg) was given from day 5 (after the pain was established), for 7 days. The degree of mechanical allodynia, cold allodynia, and heat hyperalgesia were measured on days 0, 3, 5, 7, 10 and 14 post-surgery. The open field test was carried out to assess locomotor activity of animals. Lumbar spinal cord levels of astroglia activation marker, glial fibrillary acidic protein (GFAP), microglial activation marker, ionized calcium-binding adapter molecule 1 (Iba-1), toll-like receptor 4 (TLR-4), tumor necrosis factor alpha (TNF-α), inducible isoform of nitric oxide synthase enzyme (iNOS) and apoptotic factors were quantified via western blot on days 7 and 14. CCI rats showed a significant mechanical allodynia, cold allodynia and thermal hyperalgesia, compared to sham ones on day 3, persisted up to day 14 post...Continue Reading
Citations
Jan 5, 2020·Neuromolecular Medicine·Garrett UngererZezong Gu
May 31, 2020·Metabolic Brain Disease·Mohammad Hossein SakhaeeFatemeh Forouzanfar
Jul 11, 2020·Food & Function·Esmaeil AmraieZiba Rajaei
May 21, 2020·Iranian Biomedical Journal·Malek ZareiTaraneh Moini-Zanjani
Jul 26, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zineb El GabbasAbderrahman Chait
Mar 19, 2020·Frontiers in Pharmacology·Chunxu LuoShuangyong Sun
Jun 28, 2020·Phytotherapy Research : PTR·Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh
Jul 28, 2020·Journal of Biochemical and Molecular Toxicology·Yang YaoYong Wang
Sep 2, 2020·Pharmaceuticals·Thanchanok LimcharoenPasarapa Towiwat
Sep 5, 2020·Antioxidants·Andrea F AfonsoSusana M Cardoso
Oct 17, 2018·Neural Regeneration Research·Hai-Ying CuiRong Chen
Jun 16, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Jordana Griebler LuftPatrícia Pereira
Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Feb 15, 2020·Phytotherapy Research : PTR·Javad Sharifi-RadNatália Martins
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amna KhanSalman Khan
Mar 7, 2021·Biomedicines·Taurean BrownAntiño R Allen
Feb 19, 2021·Journal of Pharmaceutical and Biomedical Analysis·Jing WangXinfeng Zhao
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad FakhriMasoumeh Jorjani
Jun 5, 2021·Nutrition and Cancer·Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh
May 18, 2021·Frontiers in Pharmacology·Mariia ShanaidaPiotr P Wieczorek
Aug 12, 2021·Indian Journal of Nephrology·Leila JafaripourHassan Ahmadvand
Jul 6, 2021·Bioengineered·Lin HuangDebing Xiang