Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells

Journal of Cellular Physiology
Yang YaoShemin Lu

Abstract

Atherosclerosis is widely known to be a chronic inflammatory disease. C-reactive protein (CRP), an important inflammatory factor, plays an essential role in the pathogenesis of atherosclerosis. Nicotine, the main addictive component of cigarette, has been shown to induce the production of CRP. The aim of this study was to investigate the effect of rosmarinic acid (RA), a polyphenol with antiinflammatory activity, on nicotine-induced elevation of CRP in vascular smooth muscle cells (VSMCs). We found that pretreatment of VSMCs with RA attenuated nicotine-induced expression of CRP in a time- and dose-dependant manner. In addition, RA also inhibited the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome and reactive oxygen species (ROS) production resulting from nicotine treatment in VSMCs. To confirm these findings in vivo, we constructed a nicotine-induced atherosclerosis rat model. RA did not significantly reduce the serum nicotine level of the rats, whereas it significantly decreased the levels of serum lipids, including concentrations of cholesterol, triglycerides, and low-density lipoprotein cholesterol, and the serum level of CRP. RA also led to diminished nicotine-induced activation of NLRP3 inflammasom...Continue Reading

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Citations

Jul 28, 2020·Journal of Biochemical and Molecular Toxicology·Yang YaoYong Wang
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yang LiuYunlun Li
Jul 16, 2020·Biomedicines·Anastasia V PoznyakAlexander N Orekhov
Jan 10, 2019·Journal of Biomedical Science·Jonatas Rafael de OliveiraLuciane Dias de Oliveira
Nov 3, 2020·Expert Opinion on Drug Discovery·Hongliang ZhangJinhui Tao
Apr 4, 2021·Biomedicines·Juan M Suárez-RiveroJosé A Sánchez-Alcázar
Mar 29, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiuxiu FuTao Yu
May 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Minglong GuanXiaoyun Fan
May 7, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongguang HanXiaoke Zheng

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