Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

Journal of Ethnopharmacology
Abdelfatteh El OmriHiroko Isoda

Abstract

This paper aimed to elucidate the traditional use of Rosmarinus officinalis through the investigation of cholinergic activities and neuronal differentiation in rat pheochromocytoma PC12 cells. These effects were examined in relation to the plant's habitat, the extraction procedure, and the major active compounds of R. officinalis. Cell viability, cell differentiation, acetylcholinesterase (AChE) activity, total choline, acetylcholine (ACh) and extracellular signal-regulated kinases (ERK1/2) were determined in PC12 cells treated with extracts and HPLC-identified polyphenols of R. officinalis originated from Tunisian semi-arid and subhumid area in comparison with nerve growth factor (NGF). R. officinalis extracts potentiated cell differentiation and significantly enhanced AChE activity in PC12 cells. The highest AChE activity was induced by semi-arid hydro-ethanolic extract (137% of control). Among HPLC-identified and screened polyphenols, carnosic acid (CA) and rosmarinic acid (RA) significantly induced cell differentiation, increased ACh level, and enhanced AChE activity in PC12 cells. U0126, inhibitor of ERK1/2, significantly reduced CA and RA effects on cell differentiation and AChE activity. R. officinalis' CA and RA exhibit...Continue Reading

References

Jan 1, 1994·Annual Review of Pharmacology and Toxicology·P Taylor, Z Radić
Feb 8, 2000·Journal of Ethnopharmacology·P C DiasJ E de Carvalho
Aug 15, 2000·Journal of Ethnopharmacology·M HalouiB Lyoussi
Apr 3, 2001·Nature Reviews. Neuroscience·H Soreq, S Seidman
Aug 9, 2002·European Journal of Pharmacology·Hiroshi TakedaTeruhiko Matsumiya
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Klara R BirikhHermona Soreq
Jul 10, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Liu Jian-HuiAn Li-Jia
Aug 1, 2006·Journal of Ethnopharmacology·Michael HeinrichManuel Pardo-de-Santayana
Oct 19, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jianhui LiuHeng Zhang
Jul 4, 2007·The Journal of Biological Chemistry·Susana Constantino Rosa SantosCarlota Saldanha
Aug 28, 2007·Journal of Ethnopharmacology·Michael AdamsMatthias Hamburger
Nov 23, 2007·Experimental Dermatology·Mitsuko KawanoHiroko Isoda
Oct 22, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cinthia M MazzantiMaria Rosa C Schetinger
Mar 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniele G MachadoAna Lúcia S Rodrigues
Apr 17, 2009·Phytotherapy Research : PTR·M F BlasinaF Dajas

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Citations

Nov 15, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Mahmoud Ben OthmanHiroko Isoda
Nov 23, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Jan 10, 2012·Brain Research·Abdelfatteh El OmriHiroko Isoda
Jun 16, 2015·BioMed Research International·Ramu VenkatesanSun Yeou Kim
Jul 31, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Jan 13, 2015·Oxidative Medicine and Cellular Longevity·Anne-Marie Arel-DubeauMaria-Grazia Martinoli
Aug 16, 2016·International Journal of Molecular Sciences·Imène AchourMaria-Grazia Martinoli
Jul 5, 2016·Chemico-biological Interactions·Heidi Q XieBin Zhao
Oct 8, 2016·Scientific Reports·Lorenzo Di Cesare MannelliCarla Ghelardini
Jan 13, 2018·Journal of the Science of Food and Agriculture·Mariem AchourRaquel Mateos
Jan 26, 2018·Basic & Clinical Pharmacology & Toxicology·Geir BjørklundRoman Lysiuk
Dec 24, 2017·BMC Complementary and Alternative Medicine·Myra O VillarealHiroko Isoda
Sep 26, 2017·Journal of Cellular and Molecular Medicine·We-Ping ChenLi-Dong Wu
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Razieh HosseiniOmidreza Firuzi
Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Jun 14, 2018·Frontiers in Pharmacology·Bushra ShalSalman Khan
Feb 11, 2021·Journal of the American College of Nutrition·Mariem AchourSaad Saguem
Jan 30, 2021·Food Research International·Mariem AchourRaquel Mateos
Apr 4, 2021·International Journal of Environmental Research and Public Health·Andrew S TubbsMichael A Grandner

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