Rostral Anterior Cingulate Cortex Morphology Predicts Treatment Response to Internet-Based Cognitive Behavioral Therapy for Depression

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging
Christian A WebbIsabelle M Rosso

Abstract

Rostral and subgenual anterior cingulate cortex (rACC and sgACC) activity and, to a lesser extent, volume have been shown to predict depressive symptom improvement across different antidepressant treatments. This study extends prior work by examining whether rACC and/or sgACC morphology predicts treatment response to Internet-based cognitive behavioral therapy (iCBT) for major depressive disorder. This is the first study to examine neural predictors of response to iCBT. Hierarchical linear modeling tested whether pretreatment rACC and sgACC volumes predicted depressive symptom improvement during a six-session (10-week) randomized clinical trial of iCBT (n = 35) versus a monitored attention control condition (n = 38). Analyses also tested whether pretreatment rACC and sgACC volumes differed between patients who achieved depression remission versus patients who did not remit. Larger pretreatment right rACC volume was a significant predictor of greater depressive symptom improvement in iCBT even when controlling for demographic (age, gender, race) and clinical (baseline depression, anhedonia, and anxiety) variables previously linked to treatment response. In addition, pretreatment right rACC volume was larger among patients receiv...Continue Reading

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References

Aug 31, 2000·The American Journal of Psychiatry·S G KornsteinM B Keller
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Dec 31, 2002·The American Journal of Psychiatry·Richard J DavidsonNed H Kalin
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Jan 5, 2006·The American Journal of Psychiatry·Madhukar H TrivediUNKNOWN STAR*D Study Team
Jun 5, 2007·Journal of Affective Disorders·Viola SpekVictor Pop
Sep 23, 2008·Journal of Affective Disorders·Jasper A J SmitsRobin B Jarrett
May 15, 2009·The Australian and New Zealand Journal of Psychiatry·Sarah PeriniGavin Andrews
Jun 25, 2009·International Journal of Geriatric Psychiatry·Faith M GunningGeorge S Alexopoulos
Jul 28, 2009·PloS One·Sergi G CostafredaCynthia H Y Fu
Jul 29, 2009·Journal of Consulting and Clinical Psychology·Jay C FournierRobert Gallop
Dec 8, 2009·Psychiatry Research·Fanny EugèneIan H Gotlib
Jan 7, 2010·JAMA : the Journal of the American Medical Association·Jay C FournierJan Fawcett
Mar 2, 2010·Neuron·Jessica R Andrews-HannaRandy L Buckner
Sep 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diego A Pizzagalli
Sep 30, 2010·Journal of Consulting and Clinical Psychology·Ellen DriessenJack J M Dekker
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Mar 25, 2011·Cognition & Emotion·Anett GyurakAmit Etkin
May 5, 2011·Social Psychiatry and Psychiatric Epidemiology·Katherine S ButtonDavid Kessler
Sep 16, 2011·Social Cognitive and Affective Neuroscience·Diane L SantessoDiego A Pizzagalli
Mar 28, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Dana L McMakinDavid A Brent
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Avram J HolmesRandy L Buckner
May 8, 2013·Journal of Consulting and Clinical Psychology·Nicholas R Forand, Robert J Derubeis
Jul 16, 2013·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Lisanne WarmerdamPim Cuijpers
Jan 9, 2014·Brain Imaging and Behavior·Paul M ThompsonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group
Jan 28, 2014·Biological Psychiatry·Callie L McGrathHelen S Mayberg
Mar 19, 2015·Nature Reviews. Neuroscience·Yi-Yuan TangMichael I Posner
Jan 9, 2016·Social Cognitive and Affective Neuroscience·Nathalie E HolzManfred Laucht
Oct 5, 2016·Depression and Anxiety·Michelle G CraskeHalina J Dour

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Citations

Jan 3, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Gerhard AnderssonPer Carlbring
Jan 31, 2020·Transcultural Psychiatry·Daina Crafa, Saskia K Nagel
Aug 15, 2019·Current Psychiatry Reports·Katharine DunlopConor Liston
Apr 9, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Giselli ScainiJoao Quevedo

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