PMID: 9550145Apr 29, 1998Paper

Rostral cerebellar malformation (rcm/rcm): a murine mutant to study regionalization of the cerebellum

The Journal of Comparative Neurology
L M Eisenman, R Brothers

Abstract

A recently described recessive mouse mutant, rostral cerebellar malformation (rcm/rcm), demonstrates a swaying gait at approximately 12 days of age (Lane et al. [1992] J. Hered. 83:315-318). The mutant cerebellar (Cb) phenotype consists of cerebellar tissue that extends rostrally, beyond the usual distinct anterior cerebellar boundary, into the midbrain (Lane et al. [1992] J. Hered. 83:315-318; Ackerman et al. [1997] Nature 386:838-842). Interestingly, the cerebellar ectopia occurs in the absence of any significant alterations in the distribution of nuclear groups within the brainstem. The ectopic Cb tissue is 1) adherent to the posterior and lateral aspects of the inferior colliculus and to the lateral aspect of the rostral brainstem and 2) contains acellular regions within the inner granular layer (igl) and ectopic, calbindin-immunoreactive Purkinje cells (PCs) deep to the igl. Within the Cb proper, PC organization, as revealed by zebrin II immunoreactivity, is generally normal. In the ectopic Cb tissue PCs also exhibit a banded zebrin distribution. Analysis of the spinocerebellar projection in the mutant suggests a lobular distribution similar to that seen in the normal mouse. Within the anterior region, however, the normal ...Continue Reading

References

Nov 29, 1991·Cell·K R ThomasM R Capecchi
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M E RossN Heintz
Jul 1, 1980·The Journal of Comparative Neurology·W S GriffinN Stampfer
Aug 1, 1995·The European Journal of Neuroscience·F Marín, L Puelles
Jan 1, 1995·Annual Review of Neuroscience·M E Hatten, N Heintz
Apr 1, 1995·The European Journal of Neuroscience·S Millet, R M Alvarado-Mallart
Jul 22, 1993·The Journal of Comparative Neurology·R Alvarez OteroR M Alvarado-Mallart
Jan 1, 1994·Current Topics in Developmental Biology·J L Rubenstein, L Puelles
Aug 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J A Napieralski, L M Eisenman
Sep 1, 1995·Mechanisms of Development·L Bally-CuifM Wassef
Mar 7, 1996·Nature·P H CrossleyG R Martin
Dec 4, 1995·The Journal of Comparative Neurology·H L Grishkat, L M Eisenman
Jan 1, 1996·Trends in Genetics : TIG·A L Joyner
Jul 8, 1996·The Journal of Comparative Neurology·L Zhang, J E Goldman
May 20, 1998·The Journal of Comparative Neurology·L M EisenmanR Hawkes
Jan 1, 1989·The European Journal of Neuroscience·Salvador Martinez, Rosa-Magda Alvarado-Mallart
Oct 1, 1961·Experimental Neurology·I L MIALE, R L SIDMAN

❮ Previous
Next ❯

Citations

Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samir KoiralaGabriel Corfas
Mar 3, 2004·Experimental Animals·Mitsuru KuwamuraTadao Serikawa
Aug 30, 2005·The Journal of Comparative Neurology·Carol L ArmstrongRichard Hawkes
Apr 17, 2007·The Journal of Comparative Neurology·Hassan MarzbanRichard Hawkes
Oct 7, 2015·The Cerebellum·Ketty LetoRichard Hawkes
Feb 2, 2021·Frontiers in Neural Circuits·G Giacomo ConsalezRichard Hawkes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.