Rostral truncation of a cyclostome, Lampetra japonica, induced by all-trans retinoic acid defines the head/trunk interface of the vertebrate body

Developmental Dynamics : an Official Publication of the American Association of Anatomists
S KurataniS Aizawa

Abstract

The effect of all-trans retinoic acid on embryogenesis was studied in a cyclostome, Lampetra japonica. Treatment with 0.05-0.5 microM retinoic acid on early gastrula and early neurula resulted in loss of the pharynx and in the rostral truncation of the neural tube. The mouth, pharynx, esophagus, heart, endostyle, and rostral brain were missing with graded severity. In the severest case, the embryo consisted only of trunk segments, especially myotomes that extended to the rostral end of the axis. The effect appeared to be dose- and stage-dependent: Rostral pharyngeal arches were more vulnerable to a lower amount of retinoic acid, and earlier treatment resulted in severer defects. The initial protrusion of the anterior axis started equally in control and retinoic acid-treated embryos, implying that the head morphogenesis is omitted in treated embryos. By identifying the number of myotomes based on the differentiation of hypobranchial muscles, there seemed to be no myotomes lost by retinoic acid-induced truncation. The rostral truncation, therefore, was not simply a limitation of the anterior axis but was restricted to the ventral portion; only the branchial arches disappeared with normally developing myotomes dorsally. The absent...Continue Reading

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Citations

Oct 18, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T F Schilling, R D Knight
May 31, 2006·International Journal of Biological Sciences·Ferdinand MarlétazMichael Schubert
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Nov 13, 2008·Genesis : the Journal of Genetics and Development·Florent Campo-PaysaaMichael Schubert
Dec 12, 2012·Development, Growth & Differentiation·Mikiko Tanaka
Apr 2, 2016·Development·Kazunori OkadaHiroshi Wada
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May 5, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rie Kusakabe, Shigeru Kuratani
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Apr 7, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael J Depew, Carol A Simpson
Apr 19, 2003·Development·David W McCauley, Marianne Bronner-Fraser
May 24, 2012·Development·Sebastian M Shimeld, Phillip C J Donoghue

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