Rostrocaudal somatotopy in the neural connections between the lateral hypothalamus and the dorsal periaqueductal gray of the rat brain.

Cellular and Molecular Neurobiology
Gislaine Garcia PelosiFernando Morgan Aguiar Corrêa

Abstract

1. The lateral hypothalamus (LH) and the dorsal periaqueductal gray area (dPAG) are two important brain structures involved in central cardiovascular control. 2. In the present study, we searched for possible rostrocaudal somatotopy in the neural connections from the three subdivisions of the LH (anterior-LHa; tuberal-LHt and posterior-LHp) to the different rostrocaudal portions of the dPAG. 3. The bidirectional neuronal tracer biotinylated-dextran-amine (BDA) was microinjected into different rostrocaudal coordinates of the dPAG (AP 3.4-2.7 mm) of male Wistar rats. One week later, animals were sacrificed and brain slices were processed and analyzed to detect neuronal efferent projections from the LH to the dPAG. 4. Neuronal cell body staining was observed along all the rostrocaudal axis of the LH when BDA was microinjected in more rostral dPAG coordinates. When the BDA was microinjected into more caudal dPAG regions, labeled neurons were observed only in the caudal portion of the LH. 5. Efferent projections from the LHa were directed only to the rostral portion of the dPAG. Projections from the rostral and medial portions of the LHt were also directed to the rostral dPAG, whereas both rostral and caudal dPAG received projection...Continue Reading

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Oct 4, 2005·Autonomic Neuroscience : Basic & Clinical·Gisela Pugliesi PajollaFernando Morgan Aguiar Corrêa
Dec 22, 2005·The European Journal of Neuroscience·Gislaine Garcia Pelosi, Fernando Morgan Aguiar Corrêa

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Citations

Jun 14, 2016·The Journal of Comparative Neurology·Alessandro BilellaMarco R Celio
Sep 17, 2013·The Journal of Pain : Official Journal of the American Pain Society·Nicholas S GregoryKathleen A Sluka
Jul 1, 2008·Dementia & Neuropsychologia·Eliasz Engelhardt, Jerson Laks

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