Rostrocaudal subregions of the ventral tegmental area are differentially impacted by chronic stress

Psychopharmacology
Francis Rodriguez BambicoJosé N Nobrega

Abstract

The ventral tegmental area (VTA) is implicated in the pathophysiology of depression and addictive disorders and is subject to the detrimental effects of stress. Chronic stress may differentially alter the activity pattern of its different subregions along the rostrocaudal and dorsoventral axes, which may relate to the variable behavioral sensitivity to stress mediated by these subregions. Here, chronic stress-exposed rats were tested for depressive-like reactivity. In situ hybridization for zif268 as a marker of neuronal activation was combined with in vivo single-unit recording of dopaminergic neurons to assess modifications in the activity of the rostral VTA (rVTA) and caudal VTA (cVTA). Changes in the expression of stress-responsive glucocorticoid receptors (GR) and brain-derived neurotrophic factor (BDNF) were also assessed. Stress-induced anhedonia-like, hyper-anxious, and passive-like responding were associated with reductions in dopaminergic burst activity in the cVTA and an increase in local GABAergic activity, particularly in GABAA receptor sensitivity. On the other hand, stress increased single-spiking activity, burst activity, and zif268 mRNA levels in the rVTA, which were associated with increased glutamatergic tonu...Continue Reading

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Citations

Jan 26, 2020·International Journal of Molecular Sciences·Pierangelo CifelliEleonora Palma
Jan 27, 2021·Neuroscience and Biobehavioral Reviews·Francesco Fornai, Stefano Puglisi-Allegra
Nov 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serena SilvestroEmanuela Mazzon
Apr 29, 2021·Journal of Psychopharmacology·Shannon C WayeFrancis Rodriguez Bambico
Nov 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Woonhee Kim, ChiHye Chung

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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