Rosuvastatin-Induced Carotid Plaque Regression in Patients With Inflammatory Joint Diseases: The Rosuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and Other Inflammatory Joint Diseases Study

Arthritis & Rheumatology
S RollefstadA Semb

Abstract

Patients with rheumatoid arthritis (RA) and carotid artery plaques have an increased risk of acute coronary syndromes. Statin treatment with the goal of achieving a low-density lipoprotein (LDL) cholesterol level of ≤1.8 mmoles/liter (≤70 mg/dl) is recommended for individuals in the general population who have carotid plaques. The aim of the ROsuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and other inflammatory joint diseases (RORA-AS) study was to evaluate the effect of 18 months of intensive lipid-lowering treatment with rosuvastatin with regard to change in carotid plaque height. Eighty-six patients (60.5% of whom were female) with carotid plaques and inflammatory joint disease (55 with RA, 21 with AS, and 10 with psoriatic arthritis) were treated with rosuvastatin to obtain the LDL cholesterol goal. Carotid plaque height was evaluated by B-mode ultrasonography. The mean ± SD age of the patients was 60.8 ± 8.5 years, and the median compliance with rosuvastatin treatment was 97.9% (interquartile range [IQR] 96.0-99.4). At baseline, the median number and height of the carotid plaques were 1.0 (range 1-8) and 1.80 mm (IQR 1.60-2.10), respectively. The mean ± SD change in carotid plaque height after 18 months of tre...Continue Reading

References

May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Mar 5, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN REVERSAL Investigators
Jun 17, 2004·Circulation·Eric de GrootJohn J P Kastelein
Mar 10, 2005·The New England Journal of Medicine·John C LaRosaUNKNOWN Treating to New Targets (TNT) Investigators
Nov 17, 2005·JAMA : the Journal of the American Medical Association·Terje R PedersenUNKNOWN Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) Study Group
Feb 24, 2006·Annals of Internal Medicine·Mary J RomanJane E Salmon
Aug 5, 2006·Vascular Medicine·Rachael A WymanJames H Stein
Oct 31, 2007·Arthritis and Rheumatism·Angel GonzalezSherine E Gabriel
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Adriaan J van GammerenChrista M Cobbaert
Jul 16, 2008·Annals of the Rheumatic Diseases·C LukasUNKNOWN Assessment of SpondyloArthritis international Society
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Jul 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Kimon S StamatelopoulosPetros P Sfikakis
Oct 20, 2009·Journal of Vascular Surgery·Nikolaos P E KadoglouChristos D Liapis
Apr 20, 2010·Annals of the New York Academy of Sciences·Miguel A Gonzalez-GayJavier Llorca
Nov 27, 2010·Annals of the Rheumatic Diseases·Jeffrey D GreenbergUNKNOWN CORRONA Investigators
Feb 10, 2011·Arthritis and Rheumatism·Matthew R EvansInmaculada del Rincón
Nov 17, 2011·The New England Journal of Medicine·Stephen J NichollsSteven E Nissen
Dec 25, 2012·Annals of the Rheumatic Diseases·Silvia RollefstadAnne Grete P Semb
Jan 17, 2013·The Journal of Rheumatology·Anne G SembJonny Hisdal
Jul 28, 2013·European Heart Journal·Rishi PuriStephen J Nicholls
Jul 24, 2014·JACC. Cardiovascular Imaging·Tasneem Z Naqvi, Ming-Sum Lee

❮ Previous
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Citations

Jul 1, 2016·Nature Reviews. Rheumatology·Anne Grete Semb, Silvia Rollefstad
Aug 8, 2015·Annals of the Rheumatic Diseases·Sara R SchoenfeldHyon K Choi
Aug 21, 2016·International Journal of Cardiology·A G SembS Rollefstad
Apr 17, 2016·Annals of the Rheumatic Diseases·Fleur M van der ValkErik S G Stroes
Feb 24, 2018·Frontiers in Medicine·Stergios SoulaidopoulosGeorge D Kitas
Oct 11, 2016·Therapeutic Advances in Musculoskeletal Disease·Anne TournadreMartin Soubrier
Oct 19, 2017·Current Atherosclerosis Reports·Michael Garshick, James A Underberg
Jul 13, 2017·Annals of the Rheumatic Diseases·Amar OzaHyon K Choi
May 20, 2015·Current Treatment Options in Neurology·Namrata Dhillon, Kimberly Liang
Jan 24, 2020·Clinical Science·Sneha RajuKathryn L Howe
Sep 28, 2018·Clinical Reviews in Allergy & Immunology·Federico CarboneMaurizio Cutolo
Jun 5, 2020·Nature Reviews. Rheumatology·Anne Grete SembSilvia Rollefstad
Oct 22, 2015·Current Neurology and Neuroscience Reports·Alicia M ZhaRéza Behrouz
Jul 2, 2019·Current Vascular Pharmacology·George E FragoulisElena Nikiphorou
Oct 26, 2021·Frontiers in Cell and Developmental Biology·Zhenyu ZhongPeizeng Yang

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