RotaC: a web-based tool for the complete genome classification of group A rotaviruses.

BMC Microbiology
Piet MaesMarc Van Ranst

Abstract

Group A rotaviruses are the most common cause of severe diarrhea in infants and children worldwide and continue to have a major global impact on childhood morbidity and mortality. In recent years, considerable research efforts have been devoted to the development of two new live, orally administered vaccines. Although both vaccines have proven to confer a good protection against severe rotavirus gastroenteritis, these vaccines will have to be screened and may have to be updated regularly to reflect temporal and spatial genotype fluctuations. In this matter, the genetic characterization of circulating and new emerging rotavirus strains will need to be compulsory and accurate. An extended classification system for rotaviruses in which all the 11 genomic RNA segments are used, has been proposed recently. The use of this classification system will help to elucidate the role of gene reassortments in the generation of genetic diversity, host range restriction, co-segregation of certain gene segments, and in adaptation to a new host species. Here we present a web-based tool that can be used for fast rotavirus genotype differentiation of all 11 group A rotavirus gene segments according to the new guidelines proposed by the Rotavirus Cl...Continue Reading

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Citations

Jul 9, 2013·Veterinary Microbiology·Esther Schoondermark-van de VenElisabeth Heylen
Oct 25, 2012·Nucleic Acids Research·Koenraad Van DoorslaerAlison A McBride
Dec 10, 2009·Future Microbiology·Jelle MatthijnssensMarc Van Ranst
Oct 1, 2011·Future Microbiology·Souvik Ghosh, Nobumichi Kobayashi
Mar 31, 2010·Emerging Infectious Diseases·Jelle MatthijnssensMarc Van Ranst
Jul 24, 2013·Emerging Infectious Diseases·Geoffrey A WeinbergMichael D Bowen
Apr 8, 2014·Database : the Journal of Biological Databases and Curation·Guang Lan ZhangVladimir Brusic
May 3, 2014·SpringerPlus·Martin M NyagaM Jeffrey Mphahlele
Jan 10, 2014·Archives of Virology·Virginie LachapelleYvan L'Homme
May 27, 2014·Emerging Infectious Diseases·Seiji P YamamotoNobuhiro Iritani
Feb 19, 2015·Viruses·Melisa Berenice BonicaElisabeth Heylen
Sep 29, 2012·Veterinary Microbiology·Olivier Martel-ParadisYvan L'Homme
May 6, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mustafizur RahmanMarc Van Ranst
May 18, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Krisztián BányaiJelle Matthijnssens
May 13, 2015·Journal of Medical Virology·Adriana LuchsMaria do Carmo Sampaio Tavares Timenetsky
Apr 2, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yashpal Singh MalikRaj Kumar Singh

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Methods Mentioned

BETA
genotyping

Software Mentioned

Paup
Clustal W
RotaC
RotaC Classification Tool

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