Rotarod impairment: catalepsy-like screening test for antipsychotic side effects

The International Journal of Neuroscience
Katrin M KirschbaumUlrich Schmitt

Abstract

Extrapyramidal motoric symptoms are casual side effects under antipsychotic medication. New generation antipsychotics are expected to have a reduced risk due to different receptor affinities. Here, haloperidol and the new generation antipsychotics, risperidone, amisulpride, and aripiprazole, were examined with both catalepsy test and rotarod performance test to screen for their usability in mice. Mice treated with haloperidol, risperidone, and aripiprazole showed dose and time-dependent impairment. Amisulpride-treated mice showed no signs of catalepsy. Catalepsy test and rotarod performance test were useful methods to detect side effects of both generation antipsychotics. Catalepsy test provided more specificity whereas the rotarod test provided higher degree of sensitivity to motor impairment including catalepsy.

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Citations

Nov 13, 2012·Human Gene Therapy·Shilpa PrabhakarGary J Brenner
Apr 20, 2017·Psychopharmacology·Janitza L Montalvo-OrtizHongxin Dong
Apr 7, 2011·Macromolecular Rapid Communications·Mirjam HemmelmannRudolf Zentel
Sep 3, 2019·Chemical Research in Toxicology·Adam M SpeenIlona Jaspers

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