PMID: 11900971Mar 20, 2002Paper

Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos

Mechanisms of Development
Anja M FaisstPeter Gruss

Abstract

The genetic cascade that governs left-right (L-R) specification is starting to be elucidated. In the mouse, the lateral asymmetry of the body axis is revealed first by the asymmetric expression of nodal, lefty2 and pitx2 in the left lateral plate mesoderm of the neurulating embryo. Here we describe a novel gene, rotatin, essential for the correct expression of the key L-R specification genes nodal, lefty and Pitx2. Embryos deficient in rotatin show also randomized heart looping and delayed neural tube closure, and fail to undergo the critical morphogenetic step of axial rotation. The amino acid sequence deduced from the cDNA is predicted to contain at least three transmembrane domains. Our results show a novel key player in the genetic cascade that determines L-R specification, and suggest a causal link between this process and axial rotation.

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Citations

Jun 7, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bishwanath ChatterjeeCecilia Lo
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