PMID: 6103936Mar 1, 1980Paper

Rotational behaviour elicited by 5-HT in the rat: evidence for an inhibitory role of 5-HT in the substantia nigra and corpus striatum

The Journal of Pharmacy and Pharmacology
T A James, M S Starr

Abstract

Unilateral intranigral microinjection of 5-HT or Wy 25093, a selective inhibitor of 5-HT uptake, elicited ipsiversive circling and a fall in striatal dopamine (DA) turnover. Conversely intranigral methysergide or unilateral lesions of the raphé-nigral 5-HT pathway produced contraversive turning and/or increased DA turnover. Both types of behaviour were accentuated by nialamide and attenuated by haloperidol. Caudate injections of 5-HT or Wy 25093 provoked contraversive turning which was increased by nialamide and hyoscine, partially diminished by haloperidol and antagonized by eserine. Ipsiversive circling was induced by intracaudate methysergide, which was potentiated by nialamide and eserine, unaffected by haloperidol and depressed by hyoscine. It is proposed that 5-HT normally subserves an inhibitory function both in the substantia nigra and corpus striatum.

References

Aug 1, 1978·Psychological Medicine·I F TullochN M Nicolaou
May 15, 1979·European Journal of Pharmacology·P C Waldmeier, A A Delini-Stula
Mar 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M J BessonJ Glowinski

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Citations

Jun 4, 1982·European Journal of Pharmacology·E SinegerJ I Székely
Jan 1, 1994·Pharmacology & Therapeutics·P ChopinM Briley
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·José L Bata-GarcíaJosé L Góngora-Alfaro
Oct 1, 1988·The International Journal of Neuroscience·R Sandyk, H Fisher
Jan 17, 2004·The European Journal of Neuroscience·J E Belforte, J H Pazo
Oct 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M S CordeiroD D Soares
Nov 1, 1983·The Journal of Pharmacy and Pharmacology·J Williams, J A Davies
Jul 21, 2017·Frontiers in Neurology·Gregory L Willis, Christopher B Freelance

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