Rotavirus: Genetics, pathogenesis and vaccine advances

Reviews in Medical Virology
Asma SadiqSadia Sattar

Abstract

Since its discovery 40 years ago, rotavirus (RV) is considered to be a major cause of infant and childhood morbidity and mortality particularly in developing countries. Nearly every child in the world under 5 years of age is at the risk of RV infection. It is estimated that 90% of RV-associated mortalities occur in developing countries of Africa and Asia. Two live oral vaccines, RotaTeq (RV5, Merck) and Rotarix (RV1, GlaxoSmithKline) have been successfully deployed to scale down the disease burden in Europe and America, but they are less effective in Africa and Asia. In April 2009, the World Health Organization recommended the inclusion of RV vaccination in national immunization programs of all countries with great emphasis in developing countries. To date, 86 countries have included RV vaccines into their national immunization programs including 41 Global Alliance for Vaccines and Immunization eligible countries. The predominant RV genotypes circulating all over the world are G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8], while G12[P6] and G12[P8] are emerging genotypes. On account of the segmented genome, RV shows an enormous genetic diversity that leads to the evolution of new genotypes that can influence the efficacy of curren...Continue Reading

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Citations

Apr 20, 2019·Transboundary and Emerging Diseases·Miguel RojasNorma Santos
Jan 30, 2020·European Journal of Public Health·Heather E BurnsCaitlin M Ni Shuilleabhain
May 18, 2020·Zoonoses and Public Health·Fábio Burack CostaNorma Santos
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May 10, 2020·Scientific Reports·Susana Vila-VicentJesús Rodríguez-Díaz
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Feb 13, 2021·Microorganisms·Jan Erik WißmannEike Steinmann
May 6, 2021·The Journal of General Virology·Yin WangJianfa Bai
Jun 4, 2021·Journal of Tropical Pediatrics·Neema NalitolelaKarim Manji
Jul 3, 2021·Viruses·Marlen Martinez-GutierrezJulian Ruiz-Saenz
Jul 6, 2021·Expert Review of Vaccines·Debasish SahaSelim Badur
Aug 17, 2021·The Pediatric Infectious Disease Journal·Howard Faden, Beverly A Schaefer
Aug 21, 2021·International Journal of Biological Macromolecules·Mayara Torquato Lima da SilvaLivia Melo Villar
Jan 9, 2022·Reviews in Medical Virology·Asma SadiqAamir Aziz

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