Rotavirus infection and intussusception in Tunisian children: implications for use of attenuated rotavirus vaccines

Journal of Pediatric Surgery
Anissa ChouikhaAndrew Duncan Steele

Abstract

A licensed rotavirus vaccine was withdrawn from use because of an increased risk of intussusception. The association of rotavirus vaccination with intussusception raised concerns about a potential link between natural rotavirus disease and intussusception. The objectives of the present study were to determine whether an epidemiological association with natural rotavirus infection existed. From 1984 to 2003, all children younger than 5 years with intussusception were retrospectively identified by medical charts, and from 1995 to 2003, a prospective surveillance study of rotavirus infection in children younger than 5 years was independently conducted. Epidemiological characteristics of intussusception and rotavirus infection were then compared. A total of 533 cases of intussusception and 146 cases of rotavirus infection were identified. The incidence of intussusception for infants younger than 1 year was 62/100,000 child-years. The age distributions of intussusception and rotavirus gastroenteritis overlapped, and a masculine predominance was noted in both cases. No significant association was observed between the monthly distribution of intussusception and rotavirus infection. The present study has not convincingly shown that rot...Continue Reading

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Citations

Jul 31, 2013·PloS One·James JiangManish M Patel
Jan 7, 2015·Australian and New Zealand Journal of Public Health·Retno Palupi-BarotoJulie E Bines
Apr 21, 2016·Journal of Medical Virology·Nuthapong UkarapolNiwat Maneekarn
Jul 17, 2013·Journal of Epidemiology and Global Health·Stephanie FletcherJohn Ellis
Nov 17, 2020·The American Journal of Emergency Medicine·Xiao Bing TangYu Zuo Bai

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