Rotavirus infection as cause of tacrolimus elevation in solid-organ-transplanted children

Pediatric Transplantation
M FrühwirthH Ellemunter

Abstract

Rotavirus (RV) is the most common cause of diarrheal illness in children. We report three solid-organ-transplanted patients in whom RV infection caused increased trough levels of the immunosuppressive macrolide tacrolimus (TAC) by mechanisms that are still under investigation. The virus was detected for longer in the feces of these patients than in infants not receiving immunosuppressive therapy. In association with short-term monitoring of blood trough levels of TAC, the dosage should be reduced early if symptoms of an acute gastroenteritis are present.

References

Nov 1, 1984·Digestive Diseases and Sciences·D Y GrahamM K Estes
Oct 1, 1994·Pharmacogenetics·J C KolarsP B Watkins
Feb 27, 1996·Transplantation·N L YancharD L Sigalet
Dec 6, 1997·Lancet·T Vesikari
Apr 16, 1999·The Journal of Nutrition·R T ZijlstraH R Gaskins

❮ Previous
Next ❯

Citations

Jul 13, 2004·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Apr 15, 2005·Journal of the American Society of Nephrology : JASN·Camille N Kotton, Jay A Fishman
Mar 19, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·I StelzmuellerH Bonatti
Feb 20, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y YinQ Pan
Feb 26, 2016·Drug Metabolism Reviews·Thomas VanhoveDirk R J Kuypers
Oct 22, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Gokhan TumgorSema Aydogdu
May 1, 2001·Pediatric Transplantation·N MittalA G Tzakis
Apr 19, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ingrid StelzmuellerHugo Bonatti
Dec 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bart D MaesYves F C Vanrenterghem
Mar 31, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H CuiX An
Feb 28, 2006·Pediatric Transplantation·Joanne F GoorhuisMarcel J I J Albers
Apr 28, 2005·The Annals of Pharmacotherapy·Robert Lee PageChristin Rogers
Nov 28, 2002·Pediatric Transplantation·Raymond Reding
Jul 30, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Clément DumondUNKNOWN French Microsporidiosis Network
Sep 1, 2021·Clinical Pharmacokinetics·Camille LenoirCaroline F Samer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Eleni KostourosRaymond Tellier
Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Jesús Reyna-FigueroaVesta Richardson
The Pediatric Infectious Disease Journal
Thea K FischerKarsten Hjelt
The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Carlos M NozawaRosa Elisa Carvalho Linhares
© 2021 Meta ULC. All rights reserved