Rotavirus live, oral, pentavalent vaccine

Clinical Therapeutics
Catherine Tom-Revzon

Abstract

On February 3, 2006, the US Food and Drug Administration (FDA) approved a live, oral, pentavalent (G1-G4, P1[8]) human-bovine reassortant rotavirus vaccine for the prevention of rotavirus gastroenteritis (RVGE) in infants in the United States. The Advisory Committee of Immunization Practices of the Centers for Disease Control and Prevention (CDC) and the American Academy of Pediatrics (AAP) recommended routine immunization of infants using 3 doses of the oral pentavalent rotavirus vaccine (PRV) at 8, 12, and 24 months of age, with the first dose administered between 6 and 12 weeks of age and subsequent doses administered at 4- to 10-week intervals. This article reviews the composition, clinical efficacy, adverse events, and cost-effectiveness associated with its use. Relevant literature was identified through searches of MEDLINE (1990-June 2007) and International Pharmaceutical Abstracts (1990-July 2007). Search terms included, but were not limited to, RotaTeq, PRV, intussusception, rotavirus infection, and cost-effectiveness. Further publications were selected from the reference lists of identified articles. Guidelines for use were identified from the Web sites of the CDC and the AAP. Two published Phase III clinical trials in...Continue Reading

Citations

Apr 2, 2010·International Journal of Epidemiology·Melinda K MunosRobert E Black
Jan 1, 2014·The Libyan Journal of Medicine·Salem AlkoshiMaznah Dahlui
Dec 17, 2014·The Libyan Journal of Medicine·Salem AlkoshiMaznah Dahlui

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