Rotavirus Species B Encodes a Functional Fusion-Associated Small Transmembrane Protein.

Journal of Virology
Julia R DillerKristen M Ogden

Abstract

Rotavirus is an important cause of diarrheal disease in young mammals. Rotavirus species A (RVA) causes most human rotavirus diarrheal disease and primarily affects infants and young children. Rotavirus species B (RVB) has been associated with sporadic outbreaks of human adult diarrheal disease. RVA and RVB are predicted to encode mostly homologous proteins but differ significantly in the proteins encoded by the NSP1 gene. In the case of RVB, the NSP1 gene encodes two putative protein products of unknown function, NSP1-1 and NSP1-2. We demonstrate that human RVB NSP1-1 mediates syncytium formation in cultured human cells. Based on sequence alignment, NSP1-1 proteins from species B, G, and I contain features consistent with fusion-associated small transmembrane (FAST) proteins, which have previously been identified in other genera of the Reoviridae family. Like some other FAST proteins, RVB NSP1-1 is predicted to have an N-terminal myristoyl modification. Addition of an N-terminal FLAG peptide disrupts NSP1-1-mediated fusion. NSP1-1 from a human RVB mediates fusion of human cells but not hamster cells and, thus, may serve as a species tropism determinant. NSP1-1 also can enhance RVA replication in human cells, both in single-cyc...Continue Reading

References

Jan 1, 1992·Archives of Virology·Z Y FangR I Glass
Nov 16, 1985·Lancet·C M ChenM A McCrae
Feb 1, 1987·Journal of Clinical Microbiology·D W BrownT H Flewett
May 1, 1987·Journal of Clinical Microbiology·S NakataJ L Melnick
Oct 1, 1984·Journal of Virology·S L VonderfechtR H Yolken
Jan 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·K W TheilD R Redman
Oct 3, 1996·The New England Journal of Medicine·F R VelázquezG M Ruiz-Palacios
Mar 1, 1996·Journal of Clinical Microbiology·T SanekataM K Estes
Feb 9, 1999·Lancet·T KrishnanS K Bhattacharya
Feb 24, 2001·Lancet·A SenT N Naik
May 8, 2003·Journal of Clinical Microbiology·Takeshi SanekataNobumichi Kobayashi
Mar 28, 2008·Molecular Biology and Evolution·Si Quang Le, Olivier Gascuel
Mar 29, 2008·PLoS Pathogens·Jayme SalsmanRoy Duncan
Jul 16, 2008·Veterinary Research Communications·K DhamaS V S Malik
Sep 29, 2009·Veterinary Microbiology·V MartellaMax Ciarlet
Nov 4, 2009·Current Protocols in Microbiology·Michelle ArnoldSarah M McDonald
Jan 1, 2010·Virology·Takeshi KobayashiTerence S Dermody
Mar 5, 2010·The Journal of General Virology·Dai YamamotoNobumichi Kobayashi
Dec 25, 2010·Journal of Medical Microbiology·Farjana SaiadaMustafizur Rahman
Jul 21, 2011·Current Topics in Membranes·Julie Boutilier, Roy Duncan
Aug 13, 2011·The Journal of General Virology·Tohru SuzukiHiroshi Tsunemitsu
Mar 21, 2012·Archives of Virology·Jelle MatthijnssensReimar Johne
Dec 15, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Eveline KindlerReimar Johne
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Oct 25, 2013·Tropical Medicine and Health·Md Mahbub AlamBasu D Pandey

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Citations

May 9, 2021·Journal of Theoretical Biology·Benjamin Jessie, Hana M Dobrovolny
Jul 6, 2021·Virus Research·Sarah CaddyUlrich Desselberger
Sep 30, 2021·Annual Review of Virology·Yuta Kanai, Takeshi Kobayashi

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