Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion

Oncotarget
Wen ZhangSongming Huang

Abstract

Acute kidney injury (AKI) has been widely recognized as an important risk factor leading to the occurrence and progression of chronic kidney disease (CKD). Thus, development of the strategies in retarding the transition of AKI to CKD is becoming a hot research field. Recently, accumulating evidence suggested a pathogenic role of mitochondrial dysfunction in both AKI and CKD. Therefore, in the present study, we evaluated the effect of mitochondrial complex 1 inhibition by rotenone on the chronic renal damage induced by acute ischemia-reperfusion. The mice were treated with 45 min unilateral renal ischemia and reperfusion (I/R) to induce an acute renal injury. After three days of I/R injury, rotenone at a dose of 200 ppm in food was administered to the mice. Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-β. Meanwhile, the enhanced inflammatory markers of TNF-α, IL-1β, IL-6, and IL-18 and apoptotic markers of Bax and caspase-3 were all significantly blunted by inhibiting mitocho...Continue Reading

References

Mar 5, 1999·Science·D C Wallace
Oct 19, 2002·Behavioural Brain Research·M Alam, W J Schmidt
Jul 3, 2003·Seminars in Nephrology·Ravindra L Mehta
Jul 13, 2007·American Journal of Physiology. Renal Physiology·Markus HörbeltTimothy A Sutton
Sep 6, 2007·American Journal of Nephrology·E M V de CavanaghL Ferder
May 7, 2011·Journal of the American Society of Nephrology : JASN·Hazel H SzetoSurya V Seshan
Sep 20, 2011·Journal of Cellular Physiology·Sébastien MichelPatricia Renard
Feb 1, 2012·Nephrology·David M SmallGlenda C Gobe
Apr 12, 2012·American Journal of Physiology. Renal Physiology·Isabel Mercedes GarcíaWalter Manucha
May 1, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jason JonesMichel Chonchol
Jun 8, 2012·Kidney International·Lakhmir S Chawla, Paul L Kimmel
Jan 31, 2013·Clinical and Experimental Pharmacology & Physiology·Prabhleen SinghLina Nordquist
Jun 4, 2013·Lancet·Norbert H LameireRaymond Vanholder
Jul 3, 2013·Journal of the American Society of Nephrology : JASN·Alexander V BirkHazel H Szeto
Oct 2, 2013·Kidney International·Neeraj Dhaun, David J Webb
Oct 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle E HeidRussell D Salter
Apr 29, 2015·The Journal of Clinical Hypertension·Dean Campbell, Matthew R Weir

❮ Previous
Next ❯

Citations

Jan 5, 2019·Journal of Cellular Physiology·Saeed FarzamfarJafar Ai
Jul 4, 2019·American Journal of Physiology. Renal Physiology·Mengqiu WuZhanjun Jia
Oct 17, 2019·International Journal of Molecular Sciences·Ricardo O S SoaresOrlando Castro-E-Silva
Sep 6, 2019·Apoptosis : an International Journal on Programmed Cell Death·Mengqiu WuZhanjun Jia
Apr 26, 2019·International Urology and Nephrology·Yunwen YangSongming Huang
Aug 8, 2020·Frontiers in Physiology·Munehiro KitadaDaisuke Koya
Jan 4, 2019·International Urology and Nephrology·Fikriye Yasemin OzatikZeynep Bayat
Oct 20, 2020·American Journal of Physiology. Renal Physiology·Mingzhu JiangAihua Zhang
Feb 10, 2021·Redox Biology·Federica De LazzariMarco Bisaglia
May 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hu HuaGuixia Ding
Sep 26, 2019·Kidney & Blood Pressure Research·Wen ZhangSongming Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
Reverse Transcription
PCR

Software Mentioned

Primer5
Image J
SPSS

Related Concepts

Related Feeds