Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease

Neurotoxicology
Michaela E JohnsonLarisa Bobrovskaya

Abstract

While people are often aware of the motor symptoms in Parkinson's disease (PD), few know of the many non-motor symptoms, which patients report have a greater impact on their quality of life. Gastrointestinal (GI) dysfunction is one of the most common non-motor symptoms, which can occur at any stage of PD, even years prior to diagnosis, and can affect all sections along the GI tract causing a range of symptoms including drooling, gastroparesis and constipation. We have investigated whether a neurotoxin model of PD induced by rotenone, a mitochondrial complex I inhibitor, is capable of reproducing the GI dysfunction seen clinically. Sprague-Dawley rats were administered 2.75 mg/kg rotenone, 5 days/week for 4 weeks, via intraperitoneal injection. Rats underwent behavioural testing, including the one-hour stool and gastric emptying tests before GI contents and tissues were collected for microbiota and histological analysis. Rats exposed to rotenone had more days with evidence of diarrhoea and significantly delayed gastric emptying, reproducing the clinical symptom of gastroparesis. Microbiota analysis revealed alterations in the small intestine and colon of rotenone-treated rats, relatively consistent with changes described in PD p...Continue Reading

References

Jan 1, 1977·Annual Review of Microbiology·D C Savage
Feb 1, 1991·The American Journal of Physiology·R D Specian, M G Oliver
Jan 1, 1995·Annual Review of Physiology·G Forstner
May 27, 1999·The American Journal of Tropical Medicine and Hygiene·A BelleyM Göettke
Apr 20, 2001·AJR. American Journal of Roentgenology·M Macari, E J Balthazar
Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ingrid B RenesAlexandra W C Einerhand
May 11, 2002·The American Journal of Gastroenterology·Christel NeutJean-Fredéric Colombel
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ingrid B RenesAlexandra W C Einerhand
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·J E ConourH R Gaskins
Oct 19, 2002·Behavioural Brain Research·M Alam, W J Schmidt
Jan 25, 2005·Infection and Immunity·Suzana D SavkovicGail Hecht
Mar 12, 2005·Southern Medical Journal·Bryan T Green, David A Tendler
Jul 5, 2006·EMBO Reports·Ann M O'Hara, Fergus Shanahan
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Aug 10, 2007·Environmental Microbiology·Mirjana Rajilić-StojanovićWillem M de Vos
Nov 9, 2007·Digestive Diseases and Sciences·Reza KhoshiniMark Pimentel
Apr 23, 2009·Neurobiology of Disease·Jason R CannonJ Timothy Greenamyre
Jul 15, 2009·Neurobiology of Disease·Robert E DroletJ Timothy Greenamyre
Oct 1, 2004·FEMS Microbiology Ecology·Irène ManginJoël Doré
Sep 22, 2009·International Journal of Experimental Pathology·Andrea M StringerDorothy M K Keefe
Dec 23, 2009·Journal of Clinical Gastroenterology·Savio C Reddymasu, Richard W McCallum
Mar 31, 2010·Journal of Clinical Microbiology·Sachi SakaguchiToshiaki Shimizu
Jan 1, 2009·Journal of Innate Immunity·Poonam DharmaniKris Chadee
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Apr 27, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Maurizio GabrielliAntonio Gasbarrini
Jun 11, 2011·Veterinary Microbiology·Hyeun Bum KimRichard E Isaacson
Jan 3, 2012·Parkinsonism & Related Disorders·Zaid S Heetun, Eamonn M M Quigley
Oct 12, 2012·Digestive Diseases and Sciences·Nina S GeorgeHenry P Parkman
May 29, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Alfonso FasanoAnna Rita Bentivoglio
Oct 30, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald Pfeiffer
Mar 19, 2014·Parkinsonism & Related Disorders·Ai Huey TanShen-Yang Lim
Dec 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Filip ScheperjansPetri Auvinen
Feb 25, 2015·Parkinsonism & Related Disorders·Erica CassaniGianni Pezzoli
Apr 8, 2015·International Journal of Molecular Sciences·Yu-Jie ZhangHua-Bin Li
Jul 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ali KeshavarzianKathleen M Shannon

❮ Previous
Next ❯

Citations

Aug 14, 2018·Beneficial Microbes·P Perez-PardoA D Kraneveld
Dec 18, 2018·Environmental Microbiology·Nina RadisavljevicBarton Brett Finlay
Mar 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi XuHui-Li Wang
Jan 11, 2020·Frontiers in Neurology·Aeja JacksonAli Keshavarzian
Mar 15, 2019·Cells·Fabiana Miraglia, Emanuela Colla
Aug 28, 2019·International Journal of Molecular Sciences·Parisa Gazerani
Dec 26, 2018·Journal of Parkinson's Disease·Honglei Chen, Beate Ritz
Nov 21, 2019·Movement Disorders Clinical Practice·Clara BullichPaula Perez-Pardo
Jan 21, 2021·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·José Cirlanio Sousa AlbuquerqueJosé Ronaldo Vasconcelos da GraÇa
Aug 14, 2020·Cell Host & Microbe·P FangE Y Hsiao
Apr 6, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María IzcoLydia Alvarez-Erviti
May 8, 2021·Chemical Research in Toxicology·Jürgen Innos, Miriam A Hickey
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Katarzyna SocałaPiotr Wlaź

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