Rotigaptide (ZP123) reverts established atrial conduction velocity slowing

Cell Communication & Adhesion
Ketil HauganJørgen S Petersen

Abstract

Rotigaptide (ZP123) increases gap junction intercellular communication (GJIC) and prevents stress-induced cardiac conduction velocity (CV) slowing. However, the effect of rotigaptide on established cardiac conduction slowing and the duration of effect on rotigaptide during washout is unknown. Metabolic stress (induced by superfusion with nonoxygenated glucose-free Tyrodes buffer) was associated with a 30% decrease in atrial CV in vehicle-treated rat atria. Rotigaptide treatment initiated after a period of 30 minutes of metabolic stress produced a rapid and significant increase in CV compared to vehicle-treated time controls. During washout of rotigaptide for 30 min (while subjected to metabolic stress), there was a minor decrease in atrial CV; however, this was not significantly different from atrial CV in a rotigaptide-treated time control group. Rotigaptide treatment rapidly normalizes established conduction slowing in atria subjected to metabolic stress. However, the cessation of effect was considerably slower than the onset of action.

References

Apr 1, 1994·Pflügers Archiv : European journal of physiology·P SchafferH Windisch
May 26, 1997·European Journal of Pharmacology·A MüllerS Dhein
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephan WengStefan Dhein
Apr 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hao QinJack M Rogers
Jun 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Anne Louise KjølbyeJorgen Søberg Petersen
Dec 19, 2003·Cell Communication & Adhesion·Stefan DheinFriedrich-Wilhelm Mohr
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Paul D Lampe, Alan F Lau
Jan 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dezhi XingJames B Martins
May 10, 2005·Journal of Cardiovascular Electrophysiology·Ketil HauganMorten Schak Nielsen
Sep 3, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Denilson C AlbuquerqueMauricio Wajngarten
Dec 14, 2005·The Journal of Pharmacology and Experimental Therapeutics·James K HennanDavid L Crandall

❮ Previous
Next ❯

Citations

Jan 30, 2009·Cardiovascular Research·Anja HagenStefan Dhein
Jan 19, 2013·Cardiovascular Diabetology·Kristine Boisen OlsenMorten Schak Nielsen
Jun 13, 2009·Journal of Electrocardiology·Bramah Singh
Sep 12, 2007·Basic & Clinical Pharmacology & Toxicology·Anne Louise KjølbyeJørgen S Petersen
Jul 27, 2006·Basic & Clinical Pharmacology & Toxicology·Ketil HauganMasamichi Hirose
Jan 27, 2011·British Journal of Pharmacology·Elke De VuystLuc Leybaert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.