Nov 1, 1987

Round window membrane permeability. An in vitro model

Acta Oto-laryngologica
L LundmanDan Bagger-Sjöbäck

Abstract

The round window membrane is regarded to be the main route for passage of potentially ototoxic substances from the middle ear cavity into the inner ear. This may be of clinical importance in acute otitis media and chronic otitis media, where sensorineural hearing impairment sometimes develops. The accuracy and reliability of an in vitro round window membrane permeability model was studied. The round window membrane of the mongolian gerbil was resected, together with its bony niche. The preparation was mounted between two glass chambers representing the middle ear and the inner ear. Passage through the round window membrane did not occur within 3 h for low density lipoprotein with a molecular weight of 2,300 kD. Only minute amounts of highly density lipoprotein, of molecular weight 115-350 kD, passed the round window membrane. The passage rate of horseradish peroxidase, which has previously been shown to pass the round window membrane in vivo, was estimated. The design of the present model is considered to make feasible controlled permeability studies on the round window membrane. Passage rates for different substances through the round window membrane can be calculated under controlled conditions by using this type of in vitro ...Continue Reading

  • References10
  • Citations11

References

  • References10
  • Citations11

Citations

Mentioned in this Paper

Psammomys
Disorder of Middle Ear
Malignant Neoplasm of Middle Ear
Entire Middle Ear
Chronic Otitis Media
Low Density Lipoprotein Cholesterol Measurement
Structure of Cochlear Window
Entire Cochlear Window
LDL-1
Body Cavities

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