PMID: 2510140Aug 1, 1989Paper

Route of administration and sex differences in the pharmacokinetics of aspirin, administered as its lysine salt

Pharmaceutical Research
L AaronsJ F Thiercelin

Abstract

One thousand milligrams of aspirin, as its lysine salt was administered intravenously, orally, and intramuscularly to nine male and nine female young healthy adult volunteers. After intravenous injection mean (+/- SD) values of clearance, steady-state volume of distribution, and terminal half-life were 12.2 +/- 2.2 ml/min/kg, 0.219 +/- 0.042 liter/kg, and 15.4 +/- 2.5 min, respectively, with no differences between males and females. Following administration aspirin was absorbed more quickly in females than in males (mean absorption times of 16.4 and 21.3 min, respectively although the bioavailability, 54%, was the same in both groups. In contrast, following intramuscular administration, aspirin was absorbed more slowly in females than males (mean absorption time of 97 and 53 min, respectively) but again the bioavailability, 89%, was the same in both groups. The data suggest that in the female the intramuscular injection is going into fat. Salicylic acid concentration-time profiles showed a less pronounced sex difference and were comparable among the routes of administration.

Citations

Apr 1, 1996·European Journal of Drug Metabolism and Pharmacokinetics·C H Gleiter, U Gundert-Remy
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D N MullerF C Luft
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Monica GandhiTerrence F Blaschke
Dec 14, 2011·Thrombosis and Haemostasis·Saskia H MevesHorst Neubauer
Nov 26, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Michael S Roberts
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Offie P SoldinDonald R Mattison
Jan 23, 2003·Clinical Pharmacokinetics·Janice B Schwartz
Apr 24, 2009·Clinical Pharmacokinetics·Offie P Soldin, Donald R Mattison
Mar 4, 2021·Pharmacological Reviews·Franck Mauvais-JarvisJoshua B Rubin
May 21, 2021·Advanced Drug Delivery Reviews·Christine M MadlaAbdul W Basit

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