PMID: 3745074Aug 1, 1986Paper

Route of administration of pentobarbital affects activity of liver glycogen phosphorylase

Journal of Applied Physiology
K J MikinesH Galbo

Abstract

Liver phosphorylase a activity in intact animals is mostly determined during anesthesia. The aim of this study was to investigate the effect of administering pentobarbital by different routes on activity of liver phosphorylase a. Rats had chronically implanted venous catheters and received pentobarbital (5 mg/100 g body wt) either intraperitoneally, as a slow intravenous infusion, or as an intravenous or intracardial bolus. Times from administration of barbiturate to sampling of the liver were 10 min, 10 min, 85 +/- 32 s (mean +/- SE), and 53 +/- 10 s, respectively. Phosphorylase a activity in % of total phosphorylase activity was 40 +/- 2, 56 +/- 4, 82 +/- 3, and 92 +/- 2, respectively, all significantly different. Thus the route of administration of pentobarbital affects the phosphorylase a activity and should be considered when evaluating this activity. This fact can only be partially explained by differences in duration before the drug takes effect. It is proposed that intraperitoneal injection of pentobarbital may anesthetize hepatic sympathetic nerves or have a direct inhibiting effect on phosphorylase a activity.

Citations

May 1, 1991·Journal of Endocrinological Investigation·H ShimizuS Kobayashi
Mar 3, 2011·The Journal of Pharmacology and Experimental Therapeutics·Tracy P TorresMasakazu Shiota
Jun 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·P MottazA Freminet
Apr 1, 1990·The American Journal of Physiology·P W ClarkE W Kraegen
Dec 1, 1987·The American Journal of Physiology·C H LangJ J Spitzer

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