Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors

Journal of Pharmaceutical Sciences
Mie Kristensen, Birger Brodin

Abstract

A number of potent drugs for the treatment of brain diseases are available. However, in order for them to reach their target site of action, they must pass the blood-brain barrier (BBB). The capillary endothelium comprises the major barrier of the BBB and allows only passive permeation of some small lipophilic molecules. Brain delivery of the larger biopharmaceuticals, which today includes an increasing number of novel drug entities, is therefore restricted, both due to their molecular size and their hydrophilic nature. Thus, the development of novel drug entities intended for the treatment of brain diseases such as neurodegenerative diseases or brain cancers require a delivery strategy for overcoming the BBB before reaching its final target within the brain. Peptide-based delivery vector is an emerging tool as shuttles for drug delivery across the BBB and one may explore receptor-mediated transcytosis, adsorptive-mediated transcytosis, and the paracellular route. The latter, however, being controversial due to the risk of co-delivery of blood-borne potential harmful substances. On the other hand, a number of studies report on drug delivery across the BBB exploiting receptor-mediated transcytosis and adsorptive-mediated transcy...Continue Reading

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Citations

Apr 23, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Cristina FusterMeritxell Teixidó
Jun 13, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bhaskar Basu, Mrinal K Ghosh
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Jan 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xue ZhouXinli Liu
Oct 9, 2020·Advanced Drug Delivery Reviews·Aroa Duro-CastanoGiuseppe Battaglia
Apr 30, 2021·International Journal of Pharmaceutics·Solmaz Mojarad-JabaliHadi Valizadeh
Dec 23, 2019·Trends in Pharmacological Sciences·Jean-Jacques LacapereVassilios Papadopoulos

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