Routine clinical laboratory tests correspond to increased serum levels of 3-hydroxy fatty acids, markers of endotoxins, in cardiosurgery patients

Archivum Immunologiae Et Therapiae Experimentalis
Leonard KraśnikAndrzej Gamian

Abstract

Endotoxemia developing during cardiosurgery as elevated endotoxin concentrations in patient's serum may prevail over 24 h after operation. A major reason is thought to be increased gut permeability resulting in endotoxin and bacterial leakage. In this study we aimed to measure endotoxin levels on samples obtained during and after cardiovascular procedures and compare them with clinical observations and laboratory test results. 3-Hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain length, chemical markers of endotoxin (lipopolysaccharide), were determined in patient sera by gas chromatography-mass spectrometry-based analysis. RESULTS were compared with routine laboratory tests: blood morphology, urine, ALT, AST, bilirubin, kidney parameters, clotting parameters, and gasometry. Of a total of 16 patients, 5 patients (group I) showed increased serum 3-OH FA levels and 11 patients (group II) did not show any change in 3-OH FA levels 24 h after operation. All group I patients revealed leukocytosis, two developed post-operative anemia. Significantly different changes were observed: the initial, pre-operative 3-OH FA levels were similar for both groups, while group I patients showed increased levels of all the studied 3-OH FAs during ...Continue Reading

Citations

Dec 25, 2012·Multidisciplinary Respiratory Medicine·Bogumiła SzponarJoanna Domagała-Kulawik
Jun 19, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Marijn M SpeeckaertJoris R Delanghe
Aug 16, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Zora Djuric

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