Routine handling of propofol prevents contamination as effectively as does strict adherence to the manufacturer's recommendations

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Ingo H LorenzArnulf Benzer

Abstract

Propofol is a potential vector of infection, because it contains no preservative. Thus, the manufacturer's specific recommendations for preparing injections or infusions go beyond the guidelines commonly used in our operating rooms for preparing other iv drugs. The purpose of the present study was to determine whether in the daily routine of an operating theatre a modified propofol handling technique can prevent contamination as effectively as do the manufacturer's handling recommendations. A total of 160 consecutive neurosurgical patients were allocated to either Group I (manufacturer's handling recommendations: i.e., 1) disinfecting propofol vials and ampoules before filling syringes; 2) replacing empty syringes; 3) discarding all material at the end of surgery); or Group II (modified propofol handling protocol: i.e., 1) refilling empty syringes; 2) renewing only the infusion line to the patient). Total contamination rates were comparable in both groups (Group I: 14/160 (8.75%), Group II: 13/160 (8.13%) (chi2= 0.074; P=0.96). Frequency of contamination was not different between groups; either in sample 1 taken at the beginning of the procedure, (Group I: 5/80 (6.25%) vs Group II: 6/80 (7.5%); chi2=0.098; P=0.76) or in sample ...Continue Reading

References

May 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M TesslerJ Mendelson
Aug 1, 1991·Archives of Ophthalmology·M J DailyK H Packo
Sep 1, 1991·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M J ArduinoM S Favero
Nov 1, 1991·Anesthesiology·A N ZacherG Evans
Aug 1, 1989·Critical Care Medicine·P M KempenR A Sawyer
Nov 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M R LessardP H Denault
Feb 1, 1985·American Journal of Epidemiology·R W HaleyT G Emori
Sep 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G J McHugh, G M Roper
Jul 1, 1995·Anesthesia and Analgesia·M B SosisE Villaflor
Jul 20, 1995·The New England Journal of Medicine·S N BennettL Stroud
Jul 20, 1995·The New England Journal of Medicine·R L Nichols, J W Smith
Feb 1, 1994·Anaesthesia·J P Warwick, D Blake
Apr 1, 1994·British Journal of Anaesthesia·M FarringtonG R Park
Oct 1, 1993·Anesthesia and Analgesia·M B Sosis, B Braverman
Oct 1, 1993·Anaesthesia·A C QuinnR M Grounds
Nov 1, 1996·Acta Anaesthesiologica Scandinavica·A Bach, J Motsch
Mar 1, 1997·European Journal of Anaesthesiology·A BachH G Sonntag
Feb 7, 1998·Anaesthesia and Intensive Care·S GraystoneD J Farrell
Jun 27, 1998·Anaesthesia and Intensive Care·S A WebbP V van Heerden
Dec 23, 1998·British Journal of Anaesthesia·R J GajrajN B Scott
Jan 23, 1999·Anesthesia and Analgesia·I WachowskiA S Clanachan
Apr 9, 1999·Anesthesia and Analgesia·M I VidovichH Y Wong
May 4, 1999·Acta Anaesthesiologica Scandinavica·T SakuragiK Dan
May 8, 2000·European Journal of Anaesthesiology·B Hart

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Citations

Jul 2, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Basem B AbdelmalakJean-Pierre Yared
Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mitchel B Sosis
Oct 11, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas Hackmann, Chris S Soder
Jun 27, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Claude A Trépanier, Martin R Lessard
Jun 27, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Wendy C E HallAlexander S Clanachan
Jan 16, 2008·The Journal of Small Animal Practice·F A StrachanR E Clutton
May 19, 2016·Emerging Infectious Diseases·Andrés Zorrilla-VacaMarek A Mirski
Sep 16, 2017·Anaesthesia and Intensive Care·A F MerryL E Fry

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