Routine pituitary suppression with leuprolide before ovarian stimulation for oocyte retrieval

Fertility and Sterility
D R MeldrumD Huynh

Abstract

Pituitary suppression with leuprolide acetate (LA) was used before and during ovarian stimulation with human menopausal gonadotropins in 45 consecutive women having their first cycle of in vitro fertilization embryo transfer (IVF-ET). As anticipated, a low rate of cycle cancellation (6.7%) was necessary for poor responses. Follicles were allowed to develop to a larger diameter than with our prior protocol without LA. On the day of human chorionic gonadotropin (hCG), 11.5 + 0.7 follicles of at least 1.0 cm were visualized; 11.7 + 0.9 oocytes were retrieved; 67.5% fertilized and 6.7 + 0.6 normal embryos were available for transfer. Of the 3.4 + 0.1 embryos transferred per patient, 24.6% implanted. The rates of clinical pregnancy per retrieval and per stimulation were 54% and 47%, respectively, of which 23.8% aborted. Routine use of LA resulted in a highly efficient level of ongoing pregnancy per initiated cycle, and therefore may produce a superior first cycle for IVF-ET.

Citations

Jan 1, 1991·Annals of the New York Academy of Sciences·M B DoyleA H Decherney
Feb 1, 1993·Journal of Assisted Reproduction and Genetics·Z Ben-Rafael, D Feldberg
Mar 1, 1995·Journal of Assisted Reproduction and Genetics·M J LevyJ L Hall
Oct 1, 1996·Journal of Assisted Reproduction and Genetics·S H KimY S Chang
Sep 25, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·T TsunodaM Suzuki
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Luiz Eduardo T AlbuquerqueCristiane R Macedo
Dec 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·F HamiltonD R Meldrum
Sep 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D MeirowJ G Schenker
May 1, 1993·Journal of Assisted Reproduction and Genetics·D C LoutradisD Aravantinos
Sep 30, 1994·Annals of the New York Academy of Sciences·J H Check
Feb 1, 1993·Journal of Assisted Reproduction and Genetics·A EbrahimJ P Van der Merwe
Aug 1, 1996·Journal of Assisted Reproduction and Genetics·D TulchinskyK Brown
Dec 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S G Awadalla, G W Randall
Feb 1, 1993·Journal of Assisted Reproduction and Genetics·J H CheckH G Adelson
Sep 5, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R MarciM Moscarini
Aug 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·J L FrederickR J Paulson
Dec 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Z Ben-RafaelD Feldberg
Dec 22, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D GrochowskiM Szamatowicz
May 29, 2002·Current Opinion in Obstetrics & Gynecology·Mohamed F Mitwally, Robert F Casper
Feb 28, 2003·Expert Opinion on Investigational Drugs·Mohamed F M Mitwally, Robert F Casper
Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·S Oehninger, G D Hodgen

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