PMID: 11343975May 10, 2001Paper

Routine surveillance endomyocardial biopsy continues to detect significant rejection late after heart transplantation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
W Q GradekWendy M Book

Abstract

The need for continued surveillance endomyocardial biopsies beyond the first year after cardiac transplantation is controversial. We evaluated the incidence of rejections requiring treatment (International Society Heart and Lung Transplantation grade 3A or greater) in patients 5 years or more after heart transplantation. We conducted a retrospective chart review of all patients who underwent at least 1 endomyocardial biopsy at our center 5 years or more after heart transplantation. A total of 461 biopsies were performed in 77 patients 5 or more years after heart transplantation. Nine episodes of grade 3A or greater rejection were identified in 8 of 77 patients (10%). During the first year, 7.6% of biopsies were grade 3A or greater. Grade 3A rejection occurred in approximately 3.5% to 4% of biopsies during years 2 to 7. The overall incidence of procedural related complications at our institution was < 0.5%. Endomyocardial biopsies continue to detect clinically significant rejection beyond 5 years after cardiac transplantation. The overall incidence of procedural related complications requiring treatment was low and none was life threatening. The absence of early rejection does not predict freedom from late rejection. Therefore, ...Continue Reading

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Citations

Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roland KlingenbergThomas J Dengler
Oct 11, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Javed ButlerC Wright Pinson
May 16, 2002·Clinical Transplantation·D H DelgadoH J Ross
Apr 24, 2010·The New England Journal of Medicine·Michael X PhamUNKNOWN IMAGE Study Group
Apr 15, 2008·Transplantation·Iman M HamourNicholas R Banner
Jun 19, 2013·Circulation. Cardiovascular Imaging·Takuya UenoMatthias Nahrendorf
Jun 26, 2010·The Journal of Clinical Investigation·Filip K SwirskiMatthias Nahrendorf
Mar 17, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Craig R ButlerIan Paterson
Jan 1, 2006·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Juliane KiloHerwig Antretter
Sep 2, 2014·European Heart Journal·Jean-Paul Duong Van HuyenXavier Jouven
Mar 2, 2011·Current Cardiovascular Imaging Reports·Yijen L WuChien Ho
Sep 26, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael MarklJames Carr
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael X PhamHannah Valantine
May 3, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Craig R ButlerIan Paterson
Jan 3, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kevin P DalyLisa Bergersen
Aug 12, 2014·Circulation. Heart Failure·Brent C LampertKenneth J Smith
Sep 3, 2013·Current Opinion in Organ Transplantation·Douglas A HillJames A de Lemos
Dec 7, 2018·Pediatric Transplantation·David M PengDoff B McElhinney
Jul 19, 2021·JACC. Cardiovascular Imaging·Donghee HanBalaji Tamarappoo
Sep 7, 2019·Chemical Reviews·Mohammad Javad HajipourMorteza Mahmoudi

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