Abstract
Previous studies have demonstrated synergy between an aminoglycoside and a beta-lactam for treating Pseudomonas aeruginosa infections. Cystic fibrosis patients are prone to infection by this bacterium, which becomes very resistant with recurrent antibiotic treatments. The purpose of this study was to evaluate the susceptibility patterns of 122 isolates of P. aeruginosa isolated from cystic fibrosis patients to five individual antibiotics (tobramycin, ceftazidime, piperacillin, ticarcillin, and imipenem) and to four antibiotic combinations (tobramycin associated with one of the other antibiotics). Strains were selected because of their resistance to individual antimicrobial agents, which ranged from 21.3% for imipenem to 56.5% for tobramycin. By using an automated broth microdilution method, we were able to demonstrate synergy against 39 strains (32%) with tobramycin-ticarcillin, against 38 strains (31%) with tobramycin-piperacillin, against 47 strains (39%) with tobramycin-ceftazidime, and against 23 strains (19%) with tobramycin-imipenem. Of the 122 isolates, 77 (63%) were rendered significantly susceptible to at least one of the four antibiotic combinations by synergy. These results suggest that when appropriate technology is...Continue Reading
References
May 1, 1978·Antimicrobial Agents and Chemotherapy·H S Heineman, W M Lofton
Feb 1, 1978·The Journal of Infectious Diseases·M C Berenbaum
Nov 1, 1991·Antimicrobial Agents and Chemotherapy·J A Korvick, V L Yu
Jan 1, 1991·Clinical Microbiology Reviews·P H Gilligan
Mar 1, 1990·Antimicrobial Agents and Chemotherapy·J A BossoJ M Matsen
Apr 1, 1990·The Journal of Antimicrobial Chemotherapy·J M ValdesW J Ritz
Sep 8, 1989·Science·B KeremL C Tsui
Feb 1, 1987·Diagnostic Microbiology and Infectious Disease·E L Chan, R J Zabransky
Apr 1, 1988·The Journal of Pediatrics·A L SmithT Rubio
Aug 1, 1988·Chest·G DöringN Høiby
Aug 1, 1988·Chest·B C Michel
Aug 1, 1988·Chest·D M Geddes
Feb 1, 1984·The Journal of Pediatrics·A IslesH Levison
May 1, 1993·Pediatric Pulmonology·J S ElbornD J Shale
Jun 1, 1993·The Journal of Antimicrobial Chemotherapy·J W MoutonA M Horrevorts
Jan 1, 1993·The Journal of Pediatrics·S C FitzSimmons
Citations
Jan 13, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B BalkeS Häussler
Nov 7, 1995·Biochimica Et Biophysica Acta·L B VogelD J Fujita
Mar 9, 2004·Journal of Microbiological Methods·Michael M Tunney, Eileen M Scott
Jun 20, 2001·FEBS Letters·P CramerA R Kornblihtt
Nov 10, 2000·Biochimica Et Biophysica Acta·H Jumaa, P J Nielsen
Sep 6, 2002·Biochimica Et Biophysica Acta·Kenneth James Howe
Apr 14, 1999·Australian and New Zealand Journal of Medicine·J M WolterJ G McCormack
Jun 24, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Y L WuV N Tariq
Aug 26, 2009·Antimicrobial Agents and Chemotherapy·Juliet E FowerakerDiana Bilton
Mar 7, 2008·Chemotherapy·Cağla Bozkurt Güzel, A Alev Gerçeker
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Patrick A FlumeUNKNOWN Clinical Practice Guidelines for Pulmonary Therapies Committee
Dec 29, 2000·Drugs·D Banerjee, D Stableforth
May 1, 2007·Clinics in Chest Medicine·Thomas Lahiri
May 15, 2003·Pediatric Pulmonology·David J SerisierMary P Carroll
Feb 22, 2005·Journal of Microbiological Methods·Fintan MoriartyMichael Tunney
Jan 24, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sie Huey LeeReginald B H Tan
Dec 6, 2014·Advanced Drug Delivery Reviews·Oana CiofuNiels Høiby
Jul 17, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Denissani Aparecida Ferrari dos SantosRoberto Martinez
Jan 5, 2010·Yonsei Medical Journal·Devrim Dundar, Metin Otkun
Jul 3, 2019·Antimicrobial Agents and Chemotherapy·Tomefa E AsempaJoseph L Kuti
Sep 5, 2019·The Cochrane Database of Systematic Reviews·Jayesh BhattAlan R Smyth
Mar 30, 2017·The Cochrane Database of Systematic Reviews·Alan R SmythSarah J Nevitt
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·S P ConwayD G Peckham
Apr 1, 2008·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Sarah K WassilJames W White
Jun 9, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan D CogenRonald L Gibson