Routine tests during follow-up of patients after primary treatment for operable breast cancer. International (Ludwig) Breast Cancer Study Group (IBCSG)

Annals of Oncology : Official Journal of the European Society for Medical Oncology
D CrivellariJ Lindtner

Abstract

Follow-up tests for patients after diagnosis and primary treatment of breast cancer are routinely performed. However, the usefulness of these follow-up parameters remains unclear. We determined the yield of a variety of blood tests used to detect the presence of overt metastatic disease. 4105 patients enrolled in International (Ludwig) Breast Cancer Study Group (IBCSG) randomized clinical trials from 1978 to 1985 were analyzed for abnormal or equivocal findings in six routine blood tests obtained every 3 months for the first two years, every six months for years 3-5 and yearly thereafter. The relationship of test results to the occurrence of overt metastatic disease was evaluated. The relapses were categorized as follows in order to estimate the yield of the different tests for relevant sites of metastases: any breast cancer relapse, bone +/- other; liver +/- other. Alkaline phosphatase alone was abnormal in a high proportion of patients with either bone metastases, liver metastases, or both. SGOT and gamma-GT were also sensitive for patients with liver metastases. Bilirubin, serum calcium, and serum creatinine were relatively insensitive indicators of relapse. Abnormal test results were reported sometime during a patient's dis...Continue Reading

Citations

Jan 18, 2006·Clinical Chemistry·Michael J Duffy
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ying XieXu-Wei Duan
Oct 17, 2017·International Journal of Colorectal Disease·Hsin-Yuan HungJy-Ming Chiang
Jun 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L LoprinziT Smith
Aug 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·G SölétormosP Dombernowsky
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus GarbeGernot Rassner
Jan 24, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A KeshaviahA Goldhirsch

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