Routine urinary detection of antihypertensive drugs for systematic evaluation of adherence to treatment in hypertensive patients

Journal of Hypertension
Idir HamdidoucheStéphane Laurent

Abstract

Nonadherence to antihypertensive therapy is an important cause of poor blood pressure control. However, to date, few effective and accurate tools exist to routinely evaluate drug nonadherence. In this observational study, performed under conditions of routine clinical practice, we included 174 patients (aged 67 ± 11 years) with treated essential hypertension who attended the outpatient hypertension clinic of a university hospital. Adherence to antihypertensive treatment was measured by using ultraperformance liquid chromatography-tandem mass spectrometry in spot urine at the time of clinical appointment and blood pressure measurement. Patients were also asked to report their adherence using a validated questionnaire (four-item Morisky Medication Adherence Scale). The prevalence of directly measured nonadherence by urine drug detection was approximately 10%. Compared with adherent patients, those who did not adhere to their treatment (n = 15) had a higher number of antihypertensive pills and drugs (P = 0.02), cotreatment with cardiovascular drugs (P < 0.05), and total concurrent medications and pills (P < 0.01). After adjustment for age, SBP and DBP were higher in nonadherent than adherent group (SBP: 146 ± 18 vs. 131 ± 14, resp...Continue Reading

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Citations

Dec 6, 2018·The Journal of Clinical Hypertension·Bernhard K KrämerBernd Krüger
Mar 29, 2019·Circulation Research·Michel Burnier, Brent M Egan
Apr 4, 2019·Blood Pressure·Cora WunderUNKNOWN European Network Coordinating Research on Renal Denervation (ENCOReD), Stefan W. Toennes
Sep 19, 2019·Revista brasileira de enfermagem·Ivana Cristina Vieira de LimaGilmara Holanda da Cunha
Aug 4, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi UmemuraNobuhito Hirawa
Sep 11, 2020·Current Cardiology Reports·S Mehrdad Hamrahian
May 12, 2018·Circulation Research·Donna K Arnett, Steven A Claas
Sep 4, 2020·Therapeutic Drug Monitoring·Stine RognstadMimi S Opdal
Dec 14, 2019·Journal of Hypertension·Neil R PoulterRoland E Schmieder
Jul 16, 2019·Thérapie·Béatrice BouhanickPeggy Gandia
Nov 26, 2019·La Presse médicale·Béatrice BouhanickPeggy Gandia
Jul 20, 2021·Hypertension·Ola Undrum BerglandFadl Elmula M Fadl Elmula
Nov 6, 2021·Hypertension·Dan LaneUNKNOWN Endorsed by the European Society of Hypertension (ESH) Working Group on Cardiovascular Pharmacotherapy and Adherence

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