Routinely collected data and patient-centred research in anaesthesia and peri-operative care: a narrative review.

Anaesthesia
R A ArmstrongR J Hinchliffe

Abstract

Randomised controlled trials are the gold standard in clinical research, but remain rare due to their expense and a perceived lack of 'real-world' applicability. At the same time, there has been an exponential increase in routinely collected data which presents opportunities for audit, quality improvement, adverse event reporting and more efficient clinical research. Registry-based research benefits from reduced cost, large sample size and real-world applicability, with methodological developments, particularly registry-based randomised controlled trials and causal inference techniques, showing promise. Limitations include data quality and validity, the need for data linkage, the restrictions of fixed data fields, regulatory barriers, and privacy and security concerns. However, the principal factor hampering current efforts is a lack of anaesthesia-specific datasets in the UK and the fact that most surgical registries do not collect any anaesthetic data. This presents an opportunity for anaesthetists, through enhanced engagement and collaboration, to influence and improve the design of these datasets and increase the value and volume of data collected. Better datasets, coupled with a growing appreciation of new analysis methodo...Continue Reading

References

Nov 25, 2003·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Nancy E KassJulia Slutsman
Dec 19, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P AylinS Ashley
Dec 7, 2007·Quality & Safety in Health Care·Bruce CampbellKieran Sweeney
Mar 11, 2008·Journal of Biomedical Informatics·Brian C Drolet, Kevin B Johnson
Aug 14, 2009·Journal of Medical Internet Research·Steven R SimonDavid W Bates
Nov 26, 2009·Anesthesiology·Sachin KheterpalKevin K Tremper
Aug 6, 2011·Methods of Information in Medicine·J Bettencourt-SilvaV Rayward-Smith
Nov 22, 2011·Best Practice & Research. Clinical Anaesthesiology·Robert E Freundlich, Sachin Kheterpal
Apr 18, 2014·Anaesthesia·D B Jumani, S H McClelland
May 27, 2014·The Journal of Arthroplasty·Sarah L WhitehouseA John Timperley
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Mark D NeumanJeffrey H Silber
Oct 4, 2014·Clinical Trials : Journal of the Society for Clinical Trials·Andrew J Vickers
Nov 20, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nanibaa' A GarrisonEllen W Clayton
Apr 24, 2016·British Journal of Anaesthesia·P S MylesUNKNOWN COMPAC-StEP Group
Jul 28, 2016·The British Journal of Surgery·N S BlencoweJ M Blazeby
Oct 22, 2016·Journal of Clinical Epidemiology·Guowei LiUNKNOWN 2016 Symposium on Registry-Based Randomized Controlled Trials in Calgary
Nov 16, 2016·Clinical Epidemiology·Kristian AntonsenLars Hyldborg Lundstrøm
May 1, 2019·Anaesthesia·M Charlesworth, A A J van Zundert
May 1, 2019·Annals of the American Thoracic Society·Andrew J AdmonMatthew W Semler
Feb 13, 2020·JAMA : the Journal of the American Medical Association·François LamontagneUNKNOWN 65 trial investigators
Apr 22, 2020·Learning Health Systems·Annabelle CumynJean-François Ethier
Jun 13, 2020·British Journal of Anaesthesia·Vijay KrishnamoorthyKarthik Raghunathan
Jul 1, 2020·British Journal of Anaesthesia·Vijay KrishnamoorthySteve K Harris

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