Roux-en-Y gastric bypass surgery alters serum metabolites and fatty acids in patients with morbid obesity

Diabetes/metabolism Research and Reviews
Nadeeja WijayatungaNaima Moustaid-Moussa

Abstract

Bariatric surgery induces significant weight loss, increases insulin sensitivity, and reduces mortality, but the underlying mechanisms are not clear. It was hypothesized that Roux-en-Y gastric bypass (RYGB) surgery improves metabolic profile along with weight loss. The objective of this pilot study was to evaluate changes in serum metabolites and fatty acids (FA) at 2 weeks and 6 months after RYGB. Serum samples were collected pre-surgery, at 2 weeks and 6 months post-surgery from 20 patients undergoing RYGB surgery. Serum non-esterified free FA (NEFA) were measured. Serum metabolites and FA were measured using nuclear magnetic resonance spectroscopy and improved direct fatty acid methyl ester synthesis and the gas chromatography/mass spectrometry method, respectively, in subjects who completed follow-up at 6 months (n = 8). Mean (standard deviation) percent total weight loss was 6.70% (1.7) and 24.91% (6.63) at 2 weeks (n = 15) and 6 months (n = 8) post-surgery, respectively. NEFA were significantly reduced at 6 months post-surgery (P = 0.001, n = 8). Serum branched chain amino acids, 2-aminobutyrate, butyrate, 2-hydroxybutyrate, 3-hydroxybutyrate, acetone, 2-methylglutarate, and 2-oxoisocaproate were significantly reduced, wh...Continue Reading

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Citations

Aug 23, 2019·Digestive Diseases and Sciences·James N Luo, Eric G Sheu
Jun 21, 2020·Journal of Diabetes Investigation·Naofumi YoshidaKen-Ichi Hirata
Sep 14, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Prince DadsonPirjo Nuutila
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Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan LiakhAdriana Mika
Feb 20, 2021·Nutrition Research·Reza Barati-BoldajiSeyed Mohammad Mazloomi
Jun 3, 2021·Children·Holger TillSusann Weihrauch-Blüher
Dec 3, 2021·Reviews in Endocrine & Metabolic Disorders·Matilde VazMariana P Monteiro

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Methods Mentioned

BETA
NMR

Software Mentioned

MetaboAnalyst

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