Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice

Obesity Surgery
Zheng HaoHans-Rudolf Berthoud

Abstract

Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective treatments for obesity and type 2 diabetes. Despite this, the mechanisms through which it acts are still not well understood. Bile acid signaling through the transmembrane G-protein-coupled receptor TGR5 has been shown to have significant effects on metabolism and has recently been reported to be necessary for the full effects of vertical sleeve gastrectomy (VSG), a bariatric surgery with similar effects to RYGB. The goal of the current study is therefore to investigate the role of bile acid signaling through TGR5 to see if it is necessary to obtain the full effects of RYGB. High-fat diet-induced obese TGR5-/- and wildtype mice (WT) were subjected to RYGB, sham surgery, or weight matching (WM) to RYGB mice via caloric restriction. Body weight, body composition, food intake, energy expenditure, glucose tolerance, insulin sensitivity, and liver weight were measured. Although the difference in fat mass 20 weeks after surgery between RYGB and sham-operated mice was slightly reduced in TGR5-/- mice when compared to wildtype mice, loss of body weight and fat mass from preoperative levels, reduction of food intake, increase of energy expenditure, and improvement...Continue Reading

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Citations

May 28, 2019·Scientific Reports·Michael B MumphreyHans-Rudolf Berthoud
Jul 28, 2020·Nutrients·Marlena M HolterBethany P Cummings
Sep 21, 2018·Current Diabetes Reports·Karolina E Zaborska, Bethany P Cummings
Oct 21, 2019·Obesity Surgery·Matthew StevensonLouis Ragolia
Jun 27, 2019·Endocrine Reviews·Jonathan D DourosDavid A D'Alessio
Aug 30, 2020·Nutrients·Marlena M HolterBethany P Cummings
Feb 19, 2021·Frontiers in Neuroscience·Laurent Gautron
Aug 14, 2020·Physiological Reviews·Alessia PerinoKristina Schoonjans
May 6, 2021·Cell Reports Medicine·Justine FaramiaFrédéric Picard
May 18, 2021·The Journal of Clinical Investigation·Hans-Rudolf BerthoudWinfried L Neuhuber
Aug 8, 2021·Endocrine Reviews·Elina AkalestouCarel W le Roux

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Methods Mentioned

BETA
gastric bypass
NMR
ELISA

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