Roxadustat: First Global Approval.

Drugs
Sohita Dhillon

Abstract

Roxadustat (Ai Rui Zhuo® in China) is an orally administered, small molecule hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that is being developed by FibroGen, in collaboration with Astellas and AstraZeneca, for the treatment of anaemia in patients with dialysis-dependent chronic kidney disease (CKD), non-dialysis-dependent CKD and in patients with myelodysplastic syndromes. The drug reversibly binds to and inhibits HIF-prolyl hydroxylase enzymes that are responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. Inhibition of these enzymes reduces HIF breakdown and promotes HIF activity, leading to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability and increases haemoglobin levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. Roxadustat is approved in China and is under regulatory review in Japan for the treatment of anaemia in patients with dialysis-dependent CKD. Studies are underway to investigate long-term cardiovascular outcomes with roxadust...Continue Reading

References

May 7, 2010·American Journal of Physiology. Renal Physiology·Volker H Haase
Aug 5, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anatole BesarabThomas B Neff
Oct 24, 2015·Journal of the American Society of Nephrology : JASN·Anatole BesarabThomas B Neff
Apr 21, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Robert ProvenzanoThomas B Neff
Jan 25, 2017·American Journal of Nephrology·Francesco LocatelliIain C Macdougall
Mar 1, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nupur Gupta, Jay B Wish
Mar 16, 2017·Advances in Therapy·Kimberly Becker, Maha Saad
Apr 4, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nan ChenFrank H Valone
Jan 18, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven Fishbane, Bruce Spinowitz
May 13, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Dorien Groenendaal-van de MeentMarloes Schaddelee
Jun 22, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tadao AkizawaMai Ueno

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Citations

Aug 30, 2019·Acta Physiologica·Lina K Sciesielski, Karin M Kirschner
Nov 15, 2019·Drug Testing and Analysis·Mario ThevisHans Geyer
Feb 27, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna LaitakariPeppi Koivunen
Oct 1, 2019·Current Opinion in Nephrology and Hypertension·Gearoid M McMahon, Ajay K Singh
May 8, 2020·International Urology and Nephrology·Xuejiao WeiYujun Du
Nov 23, 2019·Pflügers Archiv : European journal of physiology·Joachim FandreyRoland H Wenger
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pascale SulserCarsten C Scholz
Apr 17, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anna LaitakariPeppi Koivunen
Apr 10, 2020·F1000Research·Martin Richard SpäthRoman-Ulrich Müller
Aug 26, 2020·Biomedical Chromatography : BMC·Laurie De WildePeter Van Eenoo
Sep 29, 2020·F1000Research·Senthil Velan BhoopalanMitchell J Weiss
Oct 29, 2020·Chemical Communications : Chem Comm·Zhihong LiXiaojin Zhang
Jan 18, 2020·Cell·Richard A Voit, Vijay G Sankaran
Jan 27, 2021·Diabetologia·Sergiu-Bogdan Catrina, Xiaowei Zheng
Feb 7, 2021·Nature Reviews. Nephrology·Holger ScholzPontus B Persson
Feb 12, 2021·International Journal of Environmental Research and Public Health·Władysław GrzeszczakMirosław Śnit
Oct 31, 2020·Advances in Therapy·Ramy M HannaKamyar Kalantar-Zadeh
Jan 21, 2021·Cancers·Tina SchönbergerKatrin Prost-Fingerle
Feb 12, 2021·Journal of the American Society of Nephrology : JASN·Steven FishbanePablo E Pergola
Feb 13, 2021·Peptides·Thomas Kietzmann, Ville H Mäkelä
Nov 14, 2020·Anesthesia and Analgesia·Catharina Conrad, Holger K Eltzschig
Mar 30, 2021·Kidney International Supplements·Anil K Agarwal
Apr 30, 2021·The New England Journal of Medicine·Adeera Levin
Apr 26, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anna FaivreSophie de Seigneux
May 28, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Jenni MäättäPeppi Koivunen
Jun 26, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yan-Pei HouBing Li

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