PMID: 9429912Jan 16, 1998Paper

Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro

Inflammation
C FeldmanR Wilson

Abstract

The effects of the bioactive phospholipids (PL), platelet-activating factor (PAF), lyso-PAF, and lysophosphatidylcholine (LPC) on the beat frequency and structural integrity of human ciliated respiratory epithelium were studied in vitro, in the presence or absence of polymorphonuclear leukocytes (PMNL), the antimicrobial agents, roxithromycin, clarithromycin, and azithromycin and the antioxidative enzymes catalase and superoxide dismutase (SOD). All three PL caused dose-dependent slowing of ciliary beat frequency (CBF) and epithelial damage (ED) at concentrations > or = 1 microgram/ml, which were unaffected by inclusion of the antimicrobial agents and antioxidative enzymes. When epithelial strips were exposed to the combination of PMNL and PL, there was significant potentiation of ciliary dysfunction and ED, which was ameliorated by pretreatment of the PMNL with the antimicrobial agents or by inclusion of catalase, but not SOD. These results demonstrate that LPC, PAF, and lyso-PAF cause epithelial damage by direct mechanisms which are oxidant-independent, as well as by indirect mechanisms involving phagocyte-derived reactive oxidants. Macrolides and azalide antimicrobial agents may have beneficial effects on airway inflammation...Continue Reading

Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Naoto Keicho, Shoji Kudoh
Oct 19, 2004·Clinical Microbiology Reviews·Ken B Waites, Deborah F Talkington
Jun 18, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H C SteelR Anderson
May 7, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Aydanur EkiciA Kemal Erdemoğlu
Oct 16, 2004·Expert Review of Anti-infective Therapy·Margaret R Hammerschlag
Oct 16, 2004·Expert Review of Anti-infective Therapy·Riana CockeranCharles Feldman
Jul 31, 2007·Future Microbiology·F BlasiV Valenti
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May 11, 2019·PloS One·Sebastian WeisAlbrecht Hoffmeister
Jul 11, 2012·Mediators of Inflammation·Helen C SteelCharles Feldman
Apr 3, 2021·Frontiers in Microbiology·Anne-Gaëlle LeroyLise Crémet
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Feb 22, 2008·Pharmacology & Therapeutics·Masaharu ShinkaiBruce K Rubin
Nov 23, 2021·The Cochrane Database of Systematic Reviews·Krishna UndelaGiovanni Ferrara

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