Roxithromycin downregulates production of CTACK/CCL27 and MIP-3α/CCL20 from epidermal keratinocytes

Archives of Dermatological Research
Masaru KarakawaMamitaro Ohtsuki

Abstract

Cutaneous T cell-attracting chemokine (CTACK)/CCL27 and macrophage inflammatory protein (MIP)-3α/CCL20 are the major inflammatory chemokines involved in skin inflammation. The present study showed that roxithromycin (RXM) suppressed the TNFα-induced production of CCL27 and CCL20 in HaCaT keratinocytes and normal human keratinocytes (NHKs) in a dose-dependent manner. The production of CCL20 induced by TNFα was suppressed by the addition of inhibitors of nuclear factor kappa B (NFκB). RXM suppressed NFκB activity induced by TNFα. RXM, by regulating CCL27 and CCL20, may contribute to the modulation of inflammation.

References

Jul 1, 1990·The Journal of Antimicrobial Chemotherapy·M CampaA Lazzarini
Jul 1, 1987·Antimicrobial Agents and Chemotherapy·R WiseJ M Andrews
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
May 14, 1998·The Journal of Antimicrobial Chemotherapy·A Bryskier
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·J MoralesA Zlotnik
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B HomeyA Zlotnik
Sep 16, 2000·The Journal of Dermatology·M Komine, K Tamaki
Mar 13, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·N YazawaK Tamaki
Jan 24, 2002·The Journal of International Medical Research·H Akamatsu, T Horio
Feb 1, 2002·Nature Medicine·Bernhard HomeyAlbert Zlotnik
Mar 19, 2003·The Journal of Allergy and Clinical Immunology·Takashi KakinumaKunihiko Tamaki
Aug 2, 2003·Journal of the American Academy of Dermatology·Alice B Gottlieb
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Naoko KandaShinichi Watanabe
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alice B GottliebJames G Krueger
Aug 25, 2005·The Journal of Investigative Dermatology·Mayumi KomineKunihiko Tamaki
Jan 26, 2006·Experimental Dermatology·Shinji KagamiKunihiko Tamaki
Mar 11, 2006·The Journal of Investigative Dermatology·Shinji KagamiKunihiko Tamaki
May 10, 2006·British Journal of Haematology·Claudia M J M FaaijNicola E Annels
Oct 26, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·A JacobiM Hertl
May 6, 2008·Archives of Disease in Childhood·A K Akobeng
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jérôme PèneHugues Gascan
Mar 20, 2009·The Journal of Investigative Dermatology·Erin G HarperAndrew Blauvelt

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Citations

Apr 7, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xinxin CiXuming Deng

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