PMID: 11925980Apr 3, 2002Paper

Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics

Transactions of the Royal Society of Tropical Medicine and Hygiene
Stephen V GordonStewart T Cole

Abstract

The small size of their genomes made bacterial ideal model organisms for the emerging field of genomics. Elucidating the genome sequences of mycobacteria was particularly attractive owing to the difficulties inherent in their manipulation. The slow growth rate, clumping, and requirement for category III containment make manipulation of Mycobacterium tuberculosis-complex strains laborious. M. leprae presents even greater problems as it has resisted all attempts at axenic culture. Availability of genome sequence data promised to accelerate our knowledge of the fundamental biology of these organisms, and to offer clues to the basis for their virulence, tropism and persistence in the host. This article will focus on what the genome sequences of M. tuberculosis and M. leprae have taught us about these pathogens, and how comparative genomics has exposed some of the fundamental differences between the species.

References

Mar 1, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·F TekaiaS T Cole
Jun 13, 2000·Journal of Bacteriology·T C Zahrt, V Deretic
Jun 24, 2000·Research in Microbiology·R BroschS T Cole
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y A SkeikyA Campos-Neto
Mar 10, 2001·Nature·S T ColeB G Barrell
Jul 21, 2001·Tuberculosis·S V GordonR G Hewinson

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Citations

Dec 22, 2006·Experimental Dermatology·J KleinTerence J Ryan
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kerry E MauckMark C Mescher
Aug 26, 2006·The American Journal of Tropical Medicine and Hygiene·Klaus DietzLouis Molineaux
Apr 7, 2006·Journal of Clinical Microbiology·Khin Saw Aye MyintAndrew L Corwin

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