RP11-295G20.2 facilitates hepatocellular carcinoma progression via the miR-6884-3p/CCNB1 pathway.

Aging
Jing LiJie Song

Abstract

An increasing number of studies have indicated that long noncoding RNAs (lncRNAs) play an important role in the pathogenesis of hepatocellular carcinoma (HCC). In this study, we aimed to clarify the roles of RP11-295G20.2 in HCC progression and the underlying molecular mechanisms. Bioinformatics analyses based TCGA data suggested that RP11-295G20.2 was significantly upregulated in HCC tissues and increased RP11-295G20.2 expression level correlated with poor overall survival of patients with HCC. The results of RT-PCR further showed that RP11-295G20.2 was upregulated in HCC tissues and cell lines. Functionally, RP11-295G20.2 knockdown significantly inhibited the proliferation, colony formation, invasion and migration, but induced the apoptosis of HCC cells. In line with this, downregulation of RP11-295G20.2 in HCC lines markedly suppressed the tumor growth in vivo. Mechanistically, RP11-295G20.2 could upregulate CCNB1 through targeting miR-6884-3p. More importantly, our rescue experiments revealed that miR-6884-3p/CCNB1 axis was involved in RP11-295G20.2-meditated tumorigenic behaviors of HCC cells. RP11-295G20.2 can contribute to HCC progression at least partly via the miR-6884-3p/CCNB1 axis, suggesting that RP11-295G20.2 may b...Continue Reading

References

Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G CoviniE M Tan
Jul 18, 2006·Nucleic Acids Research·Jan Krüger, Marc Rehmsmeier
Jan 25, 2011·Seminars in Cell & Developmental Biology·Michael B Clark, John S Mattick
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Apr 14, 2016·Nature Communications·Irinna PapangeliHyung J Chun
Apr 14, 2016·Cancer Cell·Adam M Schmitt, Howard Y Chang
May 10, 2016·Nature Reviews. Disease Primers·Josep M LlovetGregory Gores
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Heng WuGuisheng Song
Aug 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tasnuva D KabirPeter J Leedman
Nov 16, 2017·Nature Reviews. Molecular Cell Biology·Julia D RansohoffPaul A Khavari
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Jan 11, 2018·Nature Reviews. Gastroenterology & Hepatology·Chun-Ming WongIrene Oi-Lin Ng
Feb 13, 2018·Biochemical and Biophysical Research Communications·Jianbing WuZhe Chen
May 1, 2018·Biochemical and Biophysical Research Communications·Na ChaiRui Zhang
Aug 1, 2018·Nature Reviews. Clinical Oncology·Josep M LlovetRichard S Finn
May 31, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geng QinGangqiao Zhou
Jun 12, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ju HuangBo Zhang
Jul 25, 2019·Cancer Research·Lee Jin LimCaroline G Lee
Aug 3, 2019·Nature Reviews. Gastroenterology & Hepatology·Jordi BruixMaría Reig
Aug 23, 2019·Nature Reviews. Gastroenterology & Hepatology·Katrina Ray

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Methods Mentioned

BETA
xenograft
transfection
RIP
xenografts
PCR
flow cytometry
immunoprecipitation

Software Mentioned

ImageJ
GEPIA
RNAhybrid
TargetScan
Starbase

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