Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex

Neural Development
Olivier ClémentJulian Ik-Tsen Heng

Abstract

During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriately to form functional neural circuits. The zinc finger transcriptional repressor Rp58 (also known as Znf238 or Zbtb18) is critical for coordinating corticogenesis, but its underlying molecular mechanism remains to be better characterised. Here, we demonstrate that the co-expression of Rp58 and the cyclin dependent kinase inhibitor (CDKI) p27kip1is important for E14.5-born cortical neurons to coordinate cell cycle exit and initiate their radial migration. Notably, we find that the impaired radial positioning of Rp58-deficient cortical neurons within the embryonic (E17.5) mouse cortex, as well as their multipolar to bipolar transition from the intermediate zone to the cortical plate can be restored by forced expression of p27kip1in concert with suppression of Rnd2, a downstream target gene of Rp58. Furthermore, the restorative effects of p27kip1and Rnd2 abrogation are reminiscent of suppressing RhoA signalling in Rp58-deficient cells. Our findings demonstrate functional interplay between a transcriptional regulator and a CDKI...Continue Reading

References

Feb 28, 2002·Current Opinion in Neurobiology·Carol Schuurmans, François Guillemot
May 4, 2002·Nature Reviews. Genetics·Amitabh GuptaAnthony Wynshaw-Boris
Mar 11, 2003·Annual Review of Neuroscience·Oscar Marín, John L R Rubenstein
Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Kirsi Riento, Anne J Ridley
Jul 5, 2003·Current Biology : CB·Krister WennerbergSteen H Hansen
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Apr 14, 2004·Genes & Development·Arnaud BessonJames M Roberts
Jun 29, 2004·Trends in Neurosciences·Arnold R Kriegstein, Stephen C Noctor
May 18, 2006·Genes & Development·Laurent NguyenFrançois Guillemot
May 23, 2006·Trends in Neurosciences·Joseph J LoTurco, Jilin Bai
Nov 10, 2006·The Journal of Biological Chemistry·Yasuhiro ItohYukiko Gotoh
May 22, 2007·Nature Reviews. Neuroscience·Bradley J MolyneauxJeffrey D Macklis
Dec 12, 2007·PLoS Genetics·Carrie M Garrett-EngeleJames M Roberts
Aug 12, 2008·Nature·Julian Ik-Tsen HengFrançois Guillemot
Oct 20, 2009·Trends in Neurosciences·Julian Ik-Tsen HengLaurent Nguyen
Jan 21, 2014·Nature Reviews. Cancer·Anna LasorellaAntonio Iavarone
Oct 30, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chundi XuKozo Kaibuchi
Dec 28, 2016·Current Opinion in Neurobiology·François Guillemot, Bassem A Hassan

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Citations

May 10, 2018·Annals of the New York Academy of Sciences·Masataka KasaiKatsunori Aoki
May 10, 2019·Frontiers in Cell and Developmental Biology·Anja Urbach, Otto W Witte
Jun 2, 2020·Cellular and Molecular Life Sciences : CMLS·Quentin MarlierBrigitte Malgrange
Sep 27, 2018·Brain : a Journal of Neurology·Nanako HamadaKoh-Ichi Nagata
Dec 5, 2020·Current Opinion in Neurobiology·Gonzalo Ortiz-Álvarez, Nathalie Spassky
Oct 16, 2020·Small GTPases·Sara BasbousViolaine Moreau
Jun 29, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Taiki KatsuyamaNoriaki Sasai
May 9, 2021·Biophysical Journal·Abraham Q KohrmanEszter Posfai

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Methods Mentioned

BETA
GTPase
dissection
confocal microscopy

Software Mentioned

ImageJ

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