PMID: 8592631Sep 29, 1995Paper

RP67580, a neurokinin1 receptor antagonist, decreased restraint stress-induced defecation in rat

Neuroscience Letters
K IkedaK Tomioka

Abstract

We investigated the possibility that substance P would mediate defecation in rats subjected to restraint-stress. The increases in fecal pellet output caused by restraint-stress were inhibited by a neurokinin (NK)1 receptor antagonist, RP67580 with an ED50 (95% confidence limits) value of 0.59 (0.54-0.65) mg/kg i.p. RP68651, the enantiomer of RP67580 devoid of affinity for NK1 receptors, had little effect on it. In contrast, (+/-)SR48968, an NK2 receptor antagonist, was without effect. Furthermore, capsaicin treatment (125 mg/kg i.p.) was inactive in this model. These results suggest that the activation of NK1 receptors and substance P released from intrinsic neurons of the colon would be involved in stress-induced defecation in rats.

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Citations

Jul 6, 2006·Amino Acids·K Ebner, N Singewald
Feb 13, 2001·European Journal of Pharmacology·T M BallardG A Higgins
Oct 18, 2000·Journal of Psychosomatic Research·R Maunder
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Jun 1, 1997·British Journal of Pharmacology·T CrociL Manara
Nov 11, 2009·Gastroenterología y hepatología·Luis Menchén
Feb 1, 2008·European Journal of Pharmacology·Dorota Kakol-PalmErik Lindström
Feb 13, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A V KeitaA-C Ericson
Jun 20, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CorsettiJ Tack
Nov 15, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ines SchwetzEmeran A Mayer
Oct 21, 1999·The Journal of Pharmacy and Pharmacology·J GoldhillN Selve
Mar 14, 2001·American Journal of Physiology. Cell Physiology·D MoriartyJ Goldhill
Jan 6, 2005·World Journal of Gastroenterology : WJG·Jun-Ho LaIl-Suk Yang
Oct 26, 2000·Neuropeptides·A LecciC A Maggi

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