Rph1 mediates the nutrient-limitation signaling pathway leading to transcriptional activation of autophagy

Autophagy
Amélie Bernard, Daniel J Klionsky

Abstract

To maintain proper cellular homeostasis, the magnitude of autophagy activity has to be finely tuned in response to environmental changes. Many aspects of autophagy regulation have been extensively studied: pathways integrating signals through the master regulators TORC1 and PKA lead to multiple post-translational modifications affecting the functions, protein-protein interactions, and localization of Atg proteins. The expression of several ATG genes increases sharply upon autophagy induction conditions, and defects in ATG gene expression are associated with various diseases, pointing to the importance of transcriptional regulation of autophagy. Yet, how changes in ATG gene expression affect the rate of autophagy is not well characterized, and transcriptional regulators of the autophagy pathway remain largely unknown. To identify such regulators, we analyzed the expression of several ATG genes in a library of DNA-binding protein mutants. This led to the identification of Rph1 as a master transcriptional regulator of autophagy.

Citations

Oct 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Hang YuanZhi-Liang Sun
Jan 27, 2018·The Journal of Biological Chemistry·Elizabeth Delorme-Axford, Daniel J Klionsky
Jan 9, 2020·Thoracic Cancer·Xinzhong Chang, Ruihua Dong
Jul 28, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Michael Downey

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