RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice

Current Biology : CB
Long JiangQinghua Shi

Abstract

The mammalian sex chromosomes have undergone profound changes during their evolution from an ancestral pair of autosomes [1-4]. Specifically, the X chromosome has acquired a paradoxical sex-biased function by redistributing gene contents [5, 6] and has generated a disproportionately high number of retrogenes that are located on autosomes and exhibit male-biased expression patterns [6]. Several selection-based models have been proposed to explain this phenomenon, including a model of sexual antagonism driving X inactivation (SAXI) [6-8] and a compensatory mechanism based on meiotic sex chromosome inactivation (MSCI) [6, 8-11]. However, experimental evidence correlating the function of X-chromosome-derived autosomal retrogenes with evolutionary forces remains limited [12-17]. Here, we show that the deficiency of Rpl10l, a murine autosomal retrogene of Rpl10 with testis-specific expression, disturbs ribosome biogenesis in late-prophase spermatocytes and prohibits the transition from prophase into metaphase of the first meiotic division, resulting in male infertility. Rpl10l expression compensates for the lack of Rpl10, which exhibits a broad expression pattern but is subject to MSCI during spermatogenesis. Importantly, ectopic exp...Continue Reading

Citations

Feb 27, 2020·Cells·Mathieu GabutSébastien Durand
Mar 12, 2020·The Journal of Biological Chemistry·Qian GaoQinghua Shi
Dec 12, 2018·Genetica·Jianhai ChenXiangdong Liu
Oct 30, 2019·The Journal of Experimental Medicine·Beibei ZhangQinghua Shi
Feb 25, 2019·Science China. Life Sciences·Jürgen Brosius
Jan 28, 2021·Journal of Biomolecular Structure & Dynamics·Soudabeh SabetianClaudia Cava
Feb 11, 2021·Wiley Interdisciplinary Reviews. RNA·Karl NorrisJulie Louise Aspden
Feb 13, 2021·NAR Genomics and Bioinformatics·Konstantinos A KyritsisIoannis S Vizirianakis
Nov 25, 2020·Cells·Daniela Pollutri, Marianna Penzo
Jun 3, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Basit ShahQinghua Shi
Jul 20, 2021·Reproductive Biology·Backialakshmi SekarRaghavendra Bhatta
Aug 6, 2018·Trends in Genetics : TIG·Erica L LarsonJeffrey M Good
Sep 7, 2021·Frontiers in Cell and Developmental Biology·Xiaohua JiangYuanwei Zhang

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